Crosstalk of Magnesium and Serum Lipids in Dyslipidemia and Associated Disorders: A Systematic Review
Dyslipidemia is a significant threat to public health worldwide and the identification of its pathogenic mechanisms, as well as novel lipid-lowering agents, are warranted. Magnesium (Mg) is a key element to human health and its deficiency has been linked to the development of lipid abnormalities and...
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doaj-53c5c067417f4fc9bf393132adadc2ae2021-04-22T23:06:31ZengMDPI AGNutrients2072-66432021-04-01131411141110.3390/nu13051411Crosstalk of Magnesium and Serum Lipids in Dyslipidemia and Associated Disorders: A Systematic ReviewMihnea-Alexandru Găman0Elena-Codruța Dobrică1Matei-Alexandru Cozma2Ninel-Iacobus Antonie3Ana Maria Alexandra Stănescu4Amelia Maria Găman5Camelia Cristina Diaconu6Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Pathophysiology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Gastroenterology, Colentina Clinical Hospital, 20125 Bucharest, RomaniaDepartment of Internal Medicine, Clinical Emergency Hospital of Bucharest, 14461 Bucharest, RomaniaFaculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Pathophysiology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaFaculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDyslipidemia is a significant threat to public health worldwide and the identification of its pathogenic mechanisms, as well as novel lipid-lowering agents, are warranted. Magnesium (Mg) is a key element to human health and its deficiency has been linked to the development of lipid abnormalities and related disorders, such as the metabolic syndrome, type 2 diabetes mellitus, or cardiovascular disease. In this review, we explored the associations of Mg (dietary intake, Mg concentrations in the body) and the lipid profile, as well as the impact of Mg supplementation on serum lipids. A systematic search was computed in PubMed/MEDLINE and the Cochrane Library and 3649 potentially relevant papers were detected and screened (n = 3364 following the removal of duplicates). After the removal of irrelevant manuscripts based on the screening of their titles and abstracts (n = 3037), we examined the full-texts of 327 original papers. Finally, after we applied the exclusion and inclusion criteria, a number of 124 original articles were included in this review. Overall, the data analyzed in this review point out an association of Mg concentrations in the body with serum lipids in dyslipidemia and related disorders. However, further research is warranted to clarify whether a higher intake of Mg from the diet or via supplements can influence the lipid profile and exert lipid-lowering actions.https://www.mdpi.com/2072-6643/13/5/1411magnesiummagnesemiahypomagnesemialipidscholesteroltriglycerides |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mihnea-Alexandru Găman Elena-Codruța Dobrică Matei-Alexandru Cozma Ninel-Iacobus Antonie Ana Maria Alexandra Stănescu Amelia Maria Găman Camelia Cristina Diaconu |
spellingShingle |
Mihnea-Alexandru Găman Elena-Codruța Dobrică Matei-Alexandru Cozma Ninel-Iacobus Antonie Ana Maria Alexandra Stănescu Amelia Maria Găman Camelia Cristina Diaconu Crosstalk of Magnesium and Serum Lipids in Dyslipidemia and Associated Disorders: A Systematic Review Nutrients magnesium magnesemia hypomagnesemia lipids cholesterol triglycerides |
author_facet |
Mihnea-Alexandru Găman Elena-Codruța Dobrică Matei-Alexandru Cozma Ninel-Iacobus Antonie Ana Maria Alexandra Stănescu Amelia Maria Găman Camelia Cristina Diaconu |
author_sort |
Mihnea-Alexandru Găman |
title |
Crosstalk of Magnesium and Serum Lipids in Dyslipidemia and Associated Disorders: A Systematic Review |
title_short |
Crosstalk of Magnesium and Serum Lipids in Dyslipidemia and Associated Disorders: A Systematic Review |
title_full |
Crosstalk of Magnesium and Serum Lipids in Dyslipidemia and Associated Disorders: A Systematic Review |
title_fullStr |
Crosstalk of Magnesium and Serum Lipids in Dyslipidemia and Associated Disorders: A Systematic Review |
title_full_unstemmed |
Crosstalk of Magnesium and Serum Lipids in Dyslipidemia and Associated Disorders: A Systematic Review |
title_sort |
crosstalk of magnesium and serum lipids in dyslipidemia and associated disorders: a systematic review |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2021-04-01 |
description |
Dyslipidemia is a significant threat to public health worldwide and the identification of its pathogenic mechanisms, as well as novel lipid-lowering agents, are warranted. Magnesium (Mg) is a key element to human health and its deficiency has been linked to the development of lipid abnormalities and related disorders, such as the metabolic syndrome, type 2 diabetes mellitus, or cardiovascular disease. In this review, we explored the associations of Mg (dietary intake, Mg concentrations in the body) and the lipid profile, as well as the impact of Mg supplementation on serum lipids. A systematic search was computed in PubMed/MEDLINE and the Cochrane Library and 3649 potentially relevant papers were detected and screened (n = 3364 following the removal of duplicates). After the removal of irrelevant manuscripts based on the screening of their titles and abstracts (n = 3037), we examined the full-texts of 327 original papers. Finally, after we applied the exclusion and inclusion criteria, a number of 124 original articles were included in this review. Overall, the data analyzed in this review point out an association of Mg concentrations in the body with serum lipids in dyslipidemia and related disorders. However, further research is warranted to clarify whether a higher intake of Mg from the diet or via supplements can influence the lipid profile and exert lipid-lowering actions. |
topic |
magnesium magnesemia hypomagnesemia lipids cholesterol triglycerides |
url |
https://www.mdpi.com/2072-6643/13/5/1411 |
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