Translational Medicine Study on Circulating Tumor Cell Detection in Patients with Metastatic Breast Cancer
Objective: To explore the prognostic and predictive effects of circulating tumor cell (CTC) detection in patients with metastatic breast cancer (MBC). Methods: A total of 139 patients with MBC were selected to detect the peripheral blood CTC count by CellSearch system. The survival analysis was cond...
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Third Party Medicine International Publishing Group Co. Limited
2015-06-01
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doaj-53c5cb7c6b7748bcbaa5dabcd1f856f52020-11-24T23:32:53ZengThird Party Medicine International Publishing Group Co. Limited Journal of International Translational Medicine 2227-63942015-06-0132939710.11910/2227-6394.2015.03.02.05JITM2015030205Translational Medicine Study on Circulating Tumor Cell Detection in Patients with Metastatic Breast CancerBo SHEN0Ma-qing ZHENG1Xin-yu XU2Da WEI3Department of Medical Oncology, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu, 210009, ChinaDepartment of Medical Oncology, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu, 210009, ChinaDepartment of Medical Oncology, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu, 210009, ChinaDepartment of Medical Oncology, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu, 210009, ChinaObjective: To explore the prognostic and predictive effects of circulating tumor cell (CTC) detection in patients with metastatic breast cancer (MBC). Methods: A total of 139 patients with MBC were selected to detect the peripheral blood CTC count by CellSearch system. The survival analysis was conducted according to CTC count, and multivariate Cox regression analysis was performed to analyze the factors influencing the progression-free survival (PFS), so as to diagnose the prognostic and predictive effects of CTC counts on MBC patients. Results: The rates of patients with CTC count ≥5 were 38.85% (54/139), 22.43% (24/107) and 17.27% (19/110) before treatment, 3-4 weeks after treatment and 6-8 weeks after treatment, respectively. Before treatment, the PFS of patients with CTC count ≥5 was evidently lower than those with CTC count <5, which difference was more significant along with time. HR coefficients of CTC to PFS were 1.939, 2.401 and 3.726 before treatment, 3-4 weeks after treatment and 6-8 weeks after treatment, respectively. And CTC was superior to estrogen receptor (ER) or progesterone receptor (PR) condition, human epidermal receptor 2 (HER2) condition and Eastern Cooperative Oncology Group (ECOG) score in the prognostic and predictive values of MBC patients. Conclusion: CTC count can better reflect the therapeutic efficacy, and has higher clinical predictive value in the PFS of MBC patients.http://www.jitm.hk/EN/abstract/abstract144.shtmlBreast cancerCirculating tumor cellTranslational medicinePrognosis and predictionProgression-free survival |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bo SHEN Ma-qing ZHENG Xin-yu XU Da WEI |
spellingShingle |
Bo SHEN Ma-qing ZHENG Xin-yu XU Da WEI Translational Medicine Study on Circulating Tumor Cell Detection in Patients with Metastatic Breast Cancer Journal of International Translational Medicine Breast cancer Circulating tumor cell Translational medicine Prognosis and prediction Progression-free survival |
author_facet |
Bo SHEN Ma-qing ZHENG Xin-yu XU Da WEI |
author_sort |
Bo SHEN |
title |
Translational Medicine Study on Circulating Tumor Cell Detection in Patients with Metastatic Breast Cancer |
title_short |
Translational Medicine Study on Circulating Tumor Cell Detection in Patients with Metastatic Breast Cancer |
title_full |
Translational Medicine Study on Circulating Tumor Cell Detection in Patients with Metastatic Breast Cancer |
title_fullStr |
Translational Medicine Study on Circulating Tumor Cell Detection in Patients with Metastatic Breast Cancer |
title_full_unstemmed |
Translational Medicine Study on Circulating Tumor Cell Detection in Patients with Metastatic Breast Cancer |
title_sort |
translational medicine study on circulating tumor cell detection in patients with metastatic breast cancer |
publisher |
Third Party Medicine International Publishing Group Co. Limited |
series |
Journal of International Translational Medicine |
issn |
2227-6394 |
publishDate |
2015-06-01 |
description |
Objective: To explore the prognostic and predictive effects of circulating tumor cell (CTC) detection in patients with metastatic breast cancer (MBC). Methods: A total of 139 patients with MBC were selected to detect the peripheral blood CTC count by CellSearch system. The survival analysis was conducted according to CTC count, and multivariate Cox regression analysis was performed to analyze the factors influencing the progression-free survival (PFS), so as to diagnose the prognostic and predictive effects of CTC counts on MBC patients. Results: The rates of patients with CTC count ≥5 were 38.85% (54/139), 22.43% (24/107) and 17.27% (19/110) before treatment, 3-4 weeks after treatment and 6-8 weeks after treatment, respectively. Before treatment, the PFS of patients with CTC count ≥5 was evidently lower than those with CTC count <5, which difference was more significant along with time. HR coefficients of CTC to PFS were 1.939, 2.401 and 3.726 before treatment, 3-4 weeks after treatment and 6-8 weeks after treatment, respectively. And CTC was superior to estrogen receptor (ER) or progesterone receptor (PR) condition, human epidermal receptor 2 (HER2) condition and Eastern Cooperative Oncology Group (ECOG) score in the prognostic and predictive values of MBC patients. Conclusion: CTC count can better reflect the therapeutic efficacy, and has higher clinical predictive value in the PFS of MBC patients. |
topic |
Breast cancer Circulating tumor cell Translational medicine Prognosis and prediction Progression-free survival |
url |
http://www.jitm.hk/EN/abstract/abstract144.shtml |
work_keys_str_mv |
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