Silencing COX-2 blocks PDK1/TRAF4-induced AKT activation to inhibit fibrogenesis during skeletal muscle atrophy

Silencing COX-2 blocks PDK1/TRAF4-induced AKT activation to inhibit fibrogenesis during skeletal muscle atrophy

Skeletal muscle atrophy with high prevalence can induce weakness and fatigability and place huge burden on both health and quality of life. During skeletal muscle degeneration, excessive fibroblasts and extracellular matrix (ECM) accumulated to replace and impair the resident muscle fiber and led to...

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Bibliographic Details
Main Authors: Hongtao Chen, Zhanyang Qian, Sheng Zhang, Jian Tang, Le Fang, Fan Jiang, Dawei Ge, Jie Chang, Jiang Cao, Lei Yang, Xiaojian Cao
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Redox Biology
Subjects:
COX-2
Skeletal muscle atrophy
Fibrogenesis
PDK1/AKT
TRAF4
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720309794

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http://www.sciencedirect.com/science/article/pii/S2213231720309794

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