Antimalarial activity of primaquine operates via a two-step biochemical relay

Primaquine (PQ) is a widely used anti-malaria drug, but its mechanism of action is unclear. Here, Camarda et al. show that PQ’s activity against liver and sexual Plasmodium stages depends on generation of hydroxylated-PQ metabolites (OH-PQm), which, undergoing further reactions, results in productio...

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Main Authors:	Grazia Camarda, Piyaporn Jirawatcharadech, Richard S. Priestley, Ahmed Saif, Sandra March, Michael H. L. Wong, Suet Leung, Alex B. Miller, David A. Baker, Pietro Alano, Mark J. I. Paine, Sangeeta N. Bhatia, Paul M. O’Neill, Stephen A. Ward, Giancarlo A. Biagini
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-11239-0

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spelling	doaj-53df786506df4fffaf54431621d57eba2021-05-11T12:23:20ZengNature Publishing GroupNature Communications2041-17232019-07-011011910.1038/s41467-019-11239-0Antimalarial activity of primaquine operates via a two-step biochemical relayGrazia Camarda0Piyaporn Jirawatcharadech1Richard S. Priestley2Ahmed Saif3Sandra March4Michael H. L. Wong5Suet Leung6Alex B. Miller7David A. Baker8Pietro Alano9Mark J. I. Paine10Sangeeta N. Bhatia11Paul M. O’Neill12Stephen A. Ward13Giancarlo A. Biagini14Centre for Drugs and Diagnostics Research, Tropical Disease Biology Department, Liverpool School of Tropical MedicineCentre for Drugs and Diagnostics Research, Tropical Disease Biology Department, Liverpool School of Tropical MedicineCentre for Drugs and Diagnostics Research, Tropical Disease Biology Department, Liverpool School of Tropical MedicineCentre for Drugs and Diagnostics Research, Tropical Disease Biology Department, Liverpool School of Tropical MedicineHealth Sciences and Technology/Institute for Medical Engineering and Science, Massachusetts Institute of TechnologyDepartment of Chemistry, University of LiverpoolDepartment of Chemistry, University of LiverpoolHealth Sciences and Technology/Institute for Medical Engineering and Science, Massachusetts Institute of TechnologyFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical MedicineDipartimento di Malattie Infettive, Istituto Superiore di SanitàVector Biology Department, Liverpool School of Tropical MedicineHealth Sciences and Technology/Institute for Medical Engineering and Science, Massachusetts Institute of TechnologyDepartment of Chemistry, University of LiverpoolCentre for Drugs and Diagnostics Research, Tropical Disease Biology Department, Liverpool School of Tropical MedicineCentre for Drugs and Diagnostics Research, Tropical Disease Biology Department, Liverpool School of Tropical MedicinePrimaquine (PQ) is a widely used anti-malaria drug, but its mechanism of action is unclear. Here, Camarda et al. show that PQ’s activity against liver and sexual Plasmodium stages depends on generation of hydroxylated-PQ metabolites (OH-PQm), which, undergoing further reactions, results in production of H2O2.https://doi.org/10.1038/s41467-019-11239-0
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Grazia Camarda Piyaporn Jirawatcharadech Richard S. Priestley Ahmed Saif Sandra March Michael H. L. Wong Suet Leung Alex B. Miller David A. Baker Pietro Alano Mark J. I. Paine Sangeeta N. Bhatia Paul M. O’Neill Stephen A. Ward Giancarlo A. Biagini
spellingShingle	Grazia Camarda Piyaporn Jirawatcharadech Richard S. Priestley Ahmed Saif Sandra March Michael H. L. Wong Suet Leung Alex B. Miller David A. Baker Pietro Alano Mark J. I. Paine Sangeeta N. Bhatia Paul M. O’Neill Stephen A. Ward Giancarlo A. Biagini Antimalarial activity of primaquine operates via a two-step biochemical relay Nature Communications
author_facet	Grazia Camarda Piyaporn Jirawatcharadech Richard S. Priestley Ahmed Saif Sandra March Michael H. L. Wong Suet Leung Alex B. Miller David A. Baker Pietro Alano Mark J. I. Paine Sangeeta N. Bhatia Paul M. O’Neill Stephen A. Ward Giancarlo A. Biagini
author_sort	Grazia Camarda
title	Antimalarial activity of primaquine operates via a two-step biochemical relay
title_short	Antimalarial activity of primaquine operates via a two-step biochemical relay
title_full	Antimalarial activity of primaquine operates via a two-step biochemical relay
title_fullStr	Antimalarial activity of primaquine operates via a two-step biochemical relay
title_full_unstemmed	Antimalarial activity of primaquine operates via a two-step biochemical relay
title_sort	antimalarial activity of primaquine operates via a two-step biochemical relay
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-07-01
description	Primaquine (PQ) is a widely used anti-malaria drug, but its mechanism of action is unclear. Here, Camarda et al. show that PQ’s activity against liver and sexual Plasmodium stages depends on generation of hydroxylated-PQ metabolites (OH-PQm), which, undergoing further reactions, results in production of H2O2.
url	https://doi.org/10.1038/s41467-019-11239-0
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Antimalarial activity of primaquine operates via a two-step biochemical relay

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