Cigarette smoke-induced impairment of autophagy in macrophages increases galectin-8 and inflammation
Abstract Cigarette smoke impairs autophagy, an intracellular protein degradation system, but the consequences of this defect have not been fully elucidated, especially in macrophages. Dysfunctional alveolar macrophages play an important role in chronic obstructive pulmonary disease (COPD). Here we s...
Main Authors: | Yuta Kono, Thomas Colley, Masako To, Andriana I. Papaioannou, Nicolas Mercado, Jonathan R. Baker, Yasuo To, Shinji Abe, Kosuke Haruki, Kazuhiro Ito, Peter J. Barnes |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-01-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-020-79848-0 |
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