Testosterone and androstanediol glucuronide among men in NHANES III
Abstract Background Most of the androgen replacement therapies were based on serum testosterone and without measurements of total androgen activities. Whether those with low testosterone also have low levels of androgen activity is largely unknown. We hence examined the association between testoster...
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doaj-53f7309565f246b599d7ea2c43fbdea42020-11-25T01:20:23ZengBMCBMC Public Health1471-24582018-03-011811610.1186/s12889-018-5255-6Testosterone and androstanediol glucuronide among men in NHANES IIIChuan Wei Duan0Lin Xu1Guangzhou Number 12 HospitalSchool of Public Health, Sun Yat-sen UniversityAbstract Background Most of the androgen replacement therapies were based on serum testosterone and without measurements of total androgen activities. Whether those with low testosterone also have low levels of androgen activity is largely unknown. We hence examined the association between testosterone and androstanediol glucuronide (AG), a reliable measure of androgen activity, in a nationally representative sample of US men. Methods Cross-sectional analysis was based on 1493 men from the Third National Health and Nutrition examination Survey (NHANES III) conducted from 1988 to 1991. Serum testosterone and AG were measured by immunoassay. Kernel density was used to estimate the average density of serum AG concentrations by quartiles of testosterone. Results Testosterone was weakly and positively correlated with AG (correlation coefficient = 0.18). The kernel density estimates show that the distributions are quite similar between the quartiles of testosterone. After adjustment for age, the distributions of AG in quartiles of testosterone did not change. The correlation between testosterone and AG was stronger in men with younger age, lower body mass index, non-smoking and good self-rated health and health status. Conclusions Serum testosterone is weakly correlated with total androgen activities, and the correlation is even weaker for those with poor self-rated health. Our results suggest that measurement of total androgen activity in addition to testosterone is necessary in clinical practice, especially before administration of androgen replacement therapy.http://link.springer.com/article/10.1186/s12889-018-5255-6TestosteroneAndrostanediol glucuronideCorrelation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chuan Wei Duan Lin Xu |
spellingShingle |
Chuan Wei Duan Lin Xu Testosterone and androstanediol glucuronide among men in NHANES III BMC Public Health Testosterone Androstanediol glucuronide Correlation |
author_facet |
Chuan Wei Duan Lin Xu |
author_sort |
Chuan Wei Duan |
title |
Testosterone and androstanediol glucuronide among men in NHANES III |
title_short |
Testosterone and androstanediol glucuronide among men in NHANES III |
title_full |
Testosterone and androstanediol glucuronide among men in NHANES III |
title_fullStr |
Testosterone and androstanediol glucuronide among men in NHANES III |
title_full_unstemmed |
Testosterone and androstanediol glucuronide among men in NHANES III |
title_sort |
testosterone and androstanediol glucuronide among men in nhanes iii |
publisher |
BMC |
series |
BMC Public Health |
issn |
1471-2458 |
publishDate |
2018-03-01 |
description |
Abstract Background Most of the androgen replacement therapies were based on serum testosterone and without measurements of total androgen activities. Whether those with low testosterone also have low levels of androgen activity is largely unknown. We hence examined the association between testosterone and androstanediol glucuronide (AG), a reliable measure of androgen activity, in a nationally representative sample of US men. Methods Cross-sectional analysis was based on 1493 men from the Third National Health and Nutrition examination Survey (NHANES III) conducted from 1988 to 1991. Serum testosterone and AG were measured by immunoassay. Kernel density was used to estimate the average density of serum AG concentrations by quartiles of testosterone. Results Testosterone was weakly and positively correlated with AG (correlation coefficient = 0.18). The kernel density estimates show that the distributions are quite similar between the quartiles of testosterone. After adjustment for age, the distributions of AG in quartiles of testosterone did not change. The correlation between testosterone and AG was stronger in men with younger age, lower body mass index, non-smoking and good self-rated health and health status. Conclusions Serum testosterone is weakly correlated with total androgen activities, and the correlation is even weaker for those with poor self-rated health. Our results suggest that measurement of total androgen activity in addition to testosterone is necessary in clinical practice, especially before administration of androgen replacement therapy. |
topic |
Testosterone Androstanediol glucuronide Correlation |
url |
http://link.springer.com/article/10.1186/s12889-018-5255-6 |
work_keys_str_mv |
AT chuanweiduan testosteroneandandrostanediolglucuronideamongmeninnhanesiii AT linxu testosteroneandandrostanediolglucuronideamongmeninnhanesiii |
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