Efficacy and safety of taxane-based systemic chemotherapy of advanced gastric cancer: A systematic review and meta-analysis
Abstract Taxanes are chemotherapeutic agents commonly used to treat several cancers. However, the effects of taxanes on advanced gastric cancer (AGC) are still not clear, especially when used as a first-line treatment. This systematic review and meta-analysis aims to investigate the efficacy and saf...
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doaj-53f8d5fc975a404cb5f89ca423feb58b2020-12-08T01:01:56ZengNature Publishing GroupScientific Reports2045-23222017-07-017111010.1038/s41598-017-05464-0Efficacy and safety of taxane-based systemic chemotherapy of advanced gastric cancer: A systematic review and meta-analysisJinxin Shi0Peng Gao1Yongxi Song2Xiaowan Chen3Yuan Li4Changwang Zhang5Hongchi Wang6Zhenning Wang7Department of Surgical Oncology and General Surgery, First Hospital of China Medical UniversityDepartment of Surgical Oncology and General Surgery, First Hospital of China Medical UniversityDepartment of Surgical Oncology and General Surgery, First Hospital of China Medical UniversityDepartment of Surgical Oncology and General Surgery, First Hospital of China Medical UniversityDepartment of Surgical Oncology and General Surgery, First Hospital of China Medical UniversityDepartment of Surgical Oncology and General Surgery, First Hospital of China Medical UniversityDepartment of Surgical Oncology and General Surgery, First Hospital of China Medical UniversityDepartment of Surgical Oncology and General Surgery, First Hospital of China Medical UniversityAbstract Taxanes are chemotherapeutic agents commonly used to treat several cancers. However, the effects of taxanes on advanced gastric cancer (AGC) are still not clear, especially when used as a first-line treatment. This systematic review and meta-analysis aims to investigate the efficacy and safety of taxanes as a first-line treatment of AGC. The quality of our included studies was assessed using the Cochrane risk of bias tool for RCTs and NOS scale for nRCTs, and the data of the included studies was of satisfactory quality to analyze. The outcomes included overall survival (OS), progression-free survival (PFS), overall response rate (ORR), and toxicity. Taxanes significantly improved OS (HR = 0.84, 95% CI 0.76–0.92, P = 0.0004) and had a slight effect on ORR (RR = 1.23, 95% CI 1.00–1.51, P = 0.05). However, taxanes may also increase the risks of neutropenia and leucopenia, similar to effects observed in other conventional chemotherapeutic treatments such as oxaliplatin and epirubicin. Therefore, patient characteristics including concomitant diseases, physical condition, and prior therapies should be considered before selecting taxane-based treatments for AGC.https://doi.org/10.1038/s41598-017-05464-0 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jinxin Shi Peng Gao Yongxi Song Xiaowan Chen Yuan Li Changwang Zhang Hongchi Wang Zhenning Wang |
spellingShingle |
Jinxin Shi Peng Gao Yongxi Song Xiaowan Chen Yuan Li Changwang Zhang Hongchi Wang Zhenning Wang Efficacy and safety of taxane-based systemic chemotherapy of advanced gastric cancer: A systematic review and meta-analysis Scientific Reports |
author_facet |
Jinxin Shi Peng Gao Yongxi Song Xiaowan Chen Yuan Li Changwang Zhang Hongchi Wang Zhenning Wang |
author_sort |
Jinxin Shi |
title |
Efficacy and safety of taxane-based systemic chemotherapy of advanced gastric cancer: A systematic review and meta-analysis |
title_short |
Efficacy and safety of taxane-based systemic chemotherapy of advanced gastric cancer: A systematic review and meta-analysis |
title_full |
Efficacy and safety of taxane-based systemic chemotherapy of advanced gastric cancer: A systematic review and meta-analysis |
title_fullStr |
Efficacy and safety of taxane-based systemic chemotherapy of advanced gastric cancer: A systematic review and meta-analysis |
title_full_unstemmed |
Efficacy and safety of taxane-based systemic chemotherapy of advanced gastric cancer: A systematic review and meta-analysis |
title_sort |
efficacy and safety of taxane-based systemic chemotherapy of advanced gastric cancer: a systematic review and meta-analysis |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2017-07-01 |
description |
Abstract Taxanes are chemotherapeutic agents commonly used to treat several cancers. However, the effects of taxanes on advanced gastric cancer (AGC) are still not clear, especially when used as a first-line treatment. This systematic review and meta-analysis aims to investigate the efficacy and safety of taxanes as a first-line treatment of AGC. The quality of our included studies was assessed using the Cochrane risk of bias tool for RCTs and NOS scale for nRCTs, and the data of the included studies was of satisfactory quality to analyze. The outcomes included overall survival (OS), progression-free survival (PFS), overall response rate (ORR), and toxicity. Taxanes significantly improved OS (HR = 0.84, 95% CI 0.76–0.92, P = 0.0004) and had a slight effect on ORR (RR = 1.23, 95% CI 1.00–1.51, P = 0.05). However, taxanes may also increase the risks of neutropenia and leucopenia, similar to effects observed in other conventional chemotherapeutic treatments such as oxaliplatin and epirubicin. Therefore, patient characteristics including concomitant diseases, physical condition, and prior therapies should be considered before selecting taxane-based treatments for AGC. |
url |
https://doi.org/10.1038/s41598-017-05464-0 |
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