The Effect of Hydroxyapatite Nanocrystals on Osseointegration of Titanium Implants: An In Vivo Rabbit Study
Osseointegration is dependent on implant surface characteristics, including surface chemistry and topography. The presence of nanosized calcium phosphates on the implant surface is interesting to investigate since they affect both the nanotopography and surface chemistry, forming a bone mineral rese...
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doaj-53fb917fb0c847e1ba66df2d307e0c5f2020-11-24T22:13:37ZengHindawi LimitedInternational Journal of Dentistry1687-87281687-87362014-01-01201410.1155/2014/171305171305The Effect of Hydroxyapatite Nanocrystals on Osseointegration of Titanium Implants: An In Vivo Rabbit StudyKarin Breding0Ryo Jimbo1Mariko Hayashi2Ying Xue3Kamal Mustafa4Martin Andersson5Department of Chemical and Biological Engineering, Applied Surface Chemistry, Chalmers University of Technology, 41296 Gothenburg, SwedenDepartment of Prosthodontics, Faculty of Odontology, Malmö University, 21421 Malmö, SwedenDepartment of Prosthodontics, Faculty of Odontology, Malmö University, 21421 Malmö, SwedenDepartment of Clinical Dentistry, Center for Clinical Dental Research, University of Bergen, 5020 Bergen, NorwayDepartment of Clinical Dentistry, Center for Clinical Dental Research, University of Bergen, 5020 Bergen, NorwayDepartment of Chemical and Biological Engineering, Applied Surface Chemistry, Chalmers University of Technology, 41296 Gothenburg, SwedenOsseointegration is dependent on implant surface characteristics, including surface chemistry and topography. The presence of nanosized calcium phosphates on the implant surface is interesting to investigate since they affect both the nanotopography and surface chemistry, forming a bone mineral resembling surface. In this work, the osseointegration of titanium implants with and without the presence of hydroxyapatite (HA) nanocrystals has been evaluated in vivo. The integration was examined using removal torque measurements and real-time polymerase chain reaction (RT-PCR) analysis. The study was performed using two healing time points, 3 and 12 weeks. The results showed that the torque needed to remove the implants was insignificant between the non- and HA-coated implants, both at weeks 3 and 12. The RT-PCR, however, showed significant differences for osteoblast, osteoclast, and proinflammation markers when HA nanocrystals were present.http://dx.doi.org/10.1155/2014/171305 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Karin Breding Ryo Jimbo Mariko Hayashi Ying Xue Kamal Mustafa Martin Andersson |
spellingShingle |
Karin Breding Ryo Jimbo Mariko Hayashi Ying Xue Kamal Mustafa Martin Andersson The Effect of Hydroxyapatite Nanocrystals on Osseointegration of Titanium Implants: An In Vivo Rabbit Study International Journal of Dentistry |
author_facet |
Karin Breding Ryo Jimbo Mariko Hayashi Ying Xue Kamal Mustafa Martin Andersson |
author_sort |
Karin Breding |
title |
The Effect of Hydroxyapatite Nanocrystals on Osseointegration of Titanium Implants: An In Vivo Rabbit Study |
title_short |
The Effect of Hydroxyapatite Nanocrystals on Osseointegration of Titanium Implants: An In Vivo Rabbit Study |
title_full |
The Effect of Hydroxyapatite Nanocrystals on Osseointegration of Titanium Implants: An In Vivo Rabbit Study |
title_fullStr |
The Effect of Hydroxyapatite Nanocrystals on Osseointegration of Titanium Implants: An In Vivo Rabbit Study |
title_full_unstemmed |
The Effect of Hydroxyapatite Nanocrystals on Osseointegration of Titanium Implants: An In Vivo Rabbit Study |
title_sort |
effect of hydroxyapatite nanocrystals on osseointegration of titanium implants: an in vivo rabbit study |
publisher |
Hindawi Limited |
series |
International Journal of Dentistry |
issn |
1687-8728 1687-8736 |
publishDate |
2014-01-01 |
description |
Osseointegration is dependent on implant surface characteristics, including surface chemistry and topography. The presence of nanosized calcium phosphates on the implant surface is interesting to investigate since they affect both the nanotopography and surface chemistry, forming a bone mineral resembling surface. In this work, the osseointegration of titanium implants with and without the presence of hydroxyapatite (HA) nanocrystals has been evaluated in vivo. The integration was examined using removal torque measurements and real-time polymerase chain reaction (RT-PCR) analysis. The study was performed using two healing time points, 3 and 12 weeks. The results showed that the torque needed to remove the implants was insignificant between the non- and HA-coated implants, both at weeks 3 and 12. The RT-PCR, however, showed significant differences for osteoblast, osteoclast, and proinflammation markers when HA nanocrystals were present. |
url |
http://dx.doi.org/10.1155/2014/171305 |
work_keys_str_mv |
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