The radiological, osteodesitometrical and inflammatory parameters aspects in experimentally induced chronic arthritis

• Main Authors: Mihaiela Chicu, Oana Ciureanu, Gabriela Dogaru
• Format: Article
• Language: English
• Published: Romanian Association of Balneology, Editura Balneara 2016-09-01
• Series: Balneo Research Journal
• Subjects: arthritis; DEXA; RX
• Online Access: http://bioclima.ro/Balneo127.pdf

Introduction. Chronic inflammatory rheumatic diseases currently comprise over 250 diseases mainly affecting young people and are accompanied by a high degree of physical and mental disabilities.Despite numerous attempts to identify the etiology, they still remain unknown. They were incriminated many factors: genetic, environmental, endocrinological, infectious - without specifying exactly what agent could trigger the disease. In the evolution of joint destruction were highlighted three stages: inflammatory synovitis, osteochondral destruction and fibrosis.Methods: Based on these preliminary data, the paper has proposed to make an experimental model of chronic arthritis in laboratory animals - rats Wistar, young and adults - and determine the dynamic evolution of radiographic, osteodensitometry and inflammatory parameters.Results. Young animals have presented higher radiological scores compare with the adultes; parameters of bone densitometry (T-score and Z, DEXA, BMD) at the beginning and at the end of the experiment indicated a higher level of bone destruction in group of young animals compared to the adult , while inflammatory parameters (fibrinogen, cervuloplasmina, uric acid) were equal for both groups of animals.Conclusions. Osteodensitometrical, radiological and laboratory parameters constitute the basic indicators in assessing inflammatory diseases, highlighting the intensity of the distructive osteo-articular phenomena.