Control over single-cell distribution of G1 lengths by WNT governs pluripotency.

Control over single-cell distribution of G1 lengths by WNT governs pluripotency.

The link between single-cell variation and population-level fate choices lacks a mechanistic explanation despite extensive observations of gene expression and epigenetic variation among individual cells. Here, we found that single human embryonic stem cells (hESCs) have different and biased differen...

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Bibliographic Details
Main Authors: Jiwon Jang, Dasol Han, Mahdi Golkaram, Morgane Audouard, Guojing Liu, Daniel Bridges, Stefan Hellander, Alex Chialastri, Siddharth S Dey, Linda R Petzold, Kenneth S Kosik
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-09-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3000453

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