Neuronal Reprogramming for Tissue Repair and Neuroregeneration

• Main Authors: Roxanne Hsiang-Chi Liou, Thomas L. Edwards, Keith R. Martin, Raymond Ching-Bong Wong
• Format: Article
• Language: English
• Published: MDPI AG 2020-06-01
• Series: International Journal of Molecular Sciences
• Subjects: cell reprogramming; pluripotent stem cells; retina; neuroregeneration
• Online Access: https://www.mdpi.com/1422-0067/21/12/4273

Stem cell and cell reprogramming technology represent a rapidly growing field in regenerative medicine. A number of novel neural reprogramming methods have been established, using pluripotent stem cells (PSCs) or direct reprogramming, to efficiently derive specific neuronal cell types for therapeutic applications. Both in vitro and in vivo cellular reprogramming provide diverse therapeutic pathways for modeling neurological diseases and injury repair. In particular, the retina has emerged as a promising target for clinical application of regenerative medicine. Herein, we review the potential of neuronal reprogramming to develop regenerative strategy, with a particular focus on treating retinal degenerative diseases and discuss future directions and challenges in the field.