[18F]FDG uptake of the normal spinal cord in PET/MR imaging: comparison with PET/CT imaging
Abstract Background The lack of visualization of the spinal cord hinders the evaluation of [18F]Fluoro-deoxy-glucose (FDG) uptake of the spinal cord in PET/CT. By exploiting the capability of MRI to precisely outline the spinal cord, we performed a retrospective study aimed to define normal pattern...
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doaj-54331117183c4922a590a6f2ca8095852020-11-25T03:00:38ZengSpringerOpenEJNMMI Research2191-219X2020-08-011011910.1186/s13550-020-00680-8[18F]FDG uptake of the normal spinal cord in PET/MR imaging: comparison with PET/CT imagingMarco Aiello0Vincenzo Alfano1Elena Salvatore2Carlo Cavaliere3Marco Picardi4Roberta Della Pepa5Emanuele Nicolai6Andrea Soricelli7Alessandra Vella8Marco Salvatore9Mario Mascalchi10IRCCS SDNIRCCS SDNDepartment of Neuroscience, University of Naples Federico IIIRCCS SDNDepartment of Clinical Medicine and Surgery, Hematology Section, IDepartment of Clinical Medicine and Surgery, Hematology Section, IIRCCS SDNIRCCS SDNNuclear Medicine, «Le Scotte» Hospital of SienaIRCCS SDN«Mario Serio» Department of Experimental and Clinical Biomedical Sciences, University of FlorenceAbstract Background The lack of visualization of the spinal cord hinders the evaluation of [18F]Fluoro-deoxy-glucose (FDG) uptake of the spinal cord in PET/CT. By exploiting the capability of MRI to precisely outline the spinal cord, we performed a retrospective study aimed to define normal pattern of spinal cord [18F]FDG uptake in PET/MRI. Methods Forty-one patients with lymphoma without clinical or MRI signs of spinal cord or bone marrow involvement underwent simultaneous PET and MRI acquisition using Siemens Biograph mMR after injection of 3.5 MBq/kg body weight of [18F]FDG for staging purposes. Using a custom-made software, we placed ROIs of 3 and 9 mm in diameter in the spinal cord, lumbar CSF, and vertebral marrow that were identified on MRI at 5 levels (C2, C5, T6, T12, and L3). The SUVmax, SUVmean, and the SUVmax and SUVmean normalized (NSUVmax and NSUVmean) to the liver were measured. For comparison, the same ROIs were placed in PET-CT images obtained immediately before the PET-MRI acquisition following the same tracer injection. Results On PET/MRI using the 3 mm ROI, the following average (all level excluding L3) spinal cord median (1st and 3rd quartile) values were measured: SUVmean, 1.68 (1.39 and 1.83); SUVmax, 1.92 (1.60 and 2.14); NSUVmean, 1.18 (0.93 and 1.36); and NSUVmax, 1.27 (1.01 and 1.33). Using the 9 mm ROI, the corresponding values were SUVmean, 1.41 (1.25–1.55); SUVmax, 2.41 (2.08 and 2.61); NSUVmean, 0.93 (0.79 and 1.04); and NSUVmax, 1.28 (1.02 and 1.39). Using the 3 mm ROI, the highest values of PET-MRI SUVmax, SUVmean, NSUVmax, and NSUVmean were consistently observed at C5 and the lowest at T6. Using a 9 mm ROI, the highest values were consistently observed at C5 and the lowest at T12 or T6. The spinal cord [18F]FDG-uptake values correlated with the bone marrow uptake at the same level, especially in case of NSUVmax. Comparison with PET-CT data revealed that the average SUVmax and SUVmean of the spinal cord were similar in PET-MRI and PET-CT. However, the average NSUVmax and NSUVmean of the spinal cord were higher (range 21–47%) in PET-MRI than in PET-CT. Conclusions Using a whole-body protocol, we defined the maximum and mean [18F]FDG uptake of the normal spinal cord in PET/MRI. While the observed values show the expected longitudinal distribution, they appear to be higher than those measured in PET/CT. Normalization of the SUVmax and SUVmean of the spinal cord to the liver radiotracer uptake could help in multi-institutional comparisons and studies.http://link.springer.com/article/10.1186/s13550-020-00680-8FDGPET/MRISpinal cordSUV |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marco Aiello Vincenzo Alfano Elena Salvatore Carlo Cavaliere Marco Picardi Roberta Della Pepa Emanuele Nicolai Andrea Soricelli Alessandra Vella Marco Salvatore Mario Mascalchi |
spellingShingle |
Marco Aiello Vincenzo Alfano Elena Salvatore Carlo Cavaliere Marco Picardi Roberta Della Pepa Emanuele Nicolai Andrea Soricelli Alessandra Vella Marco Salvatore Mario Mascalchi [18F]FDG uptake of the normal spinal cord in PET/MR imaging: comparison with PET/CT imaging EJNMMI Research FDG PET/MRI Spinal cord SUV |
author_facet |
Marco Aiello Vincenzo Alfano Elena Salvatore Carlo Cavaliere Marco Picardi Roberta Della Pepa Emanuele Nicolai Andrea Soricelli Alessandra Vella Marco Salvatore Mario Mascalchi |
author_sort |
Marco Aiello |
title |
[18F]FDG uptake of the normal spinal cord in PET/MR imaging: comparison with PET/CT imaging |
title_short |
[18F]FDG uptake of the normal spinal cord in PET/MR imaging: comparison with PET/CT imaging |
title_full |
[18F]FDG uptake of the normal spinal cord in PET/MR imaging: comparison with PET/CT imaging |
title_fullStr |
[18F]FDG uptake of the normal spinal cord in PET/MR imaging: comparison with PET/CT imaging |
title_full_unstemmed |
[18F]FDG uptake of the normal spinal cord in PET/MR imaging: comparison with PET/CT imaging |
title_sort |
[18f]fdg uptake of the normal spinal cord in pet/mr imaging: comparison with pet/ct imaging |
publisher |
SpringerOpen |
series |
EJNMMI Research |
issn |
2191-219X |
publishDate |
2020-08-01 |
description |
Abstract Background The lack of visualization of the spinal cord hinders the evaluation of [18F]Fluoro-deoxy-glucose (FDG) uptake of the spinal cord in PET/CT. By exploiting the capability of MRI to precisely outline the spinal cord, we performed a retrospective study aimed to define normal pattern of spinal cord [18F]FDG uptake in PET/MRI. Methods Forty-one patients with lymphoma without clinical or MRI signs of spinal cord or bone marrow involvement underwent simultaneous PET and MRI acquisition using Siemens Biograph mMR after injection of 3.5 MBq/kg body weight of [18F]FDG for staging purposes. Using a custom-made software, we placed ROIs of 3 and 9 mm in diameter in the spinal cord, lumbar CSF, and vertebral marrow that were identified on MRI at 5 levels (C2, C5, T6, T12, and L3). The SUVmax, SUVmean, and the SUVmax and SUVmean normalized (NSUVmax and NSUVmean) to the liver were measured. For comparison, the same ROIs were placed in PET-CT images obtained immediately before the PET-MRI acquisition following the same tracer injection. Results On PET/MRI using the 3 mm ROI, the following average (all level excluding L3) spinal cord median (1st and 3rd quartile) values were measured: SUVmean, 1.68 (1.39 and 1.83); SUVmax, 1.92 (1.60 and 2.14); NSUVmean, 1.18 (0.93 and 1.36); and NSUVmax, 1.27 (1.01 and 1.33). Using the 9 mm ROI, the corresponding values were SUVmean, 1.41 (1.25–1.55); SUVmax, 2.41 (2.08 and 2.61); NSUVmean, 0.93 (0.79 and 1.04); and NSUVmax, 1.28 (1.02 and 1.39). Using the 3 mm ROI, the highest values of PET-MRI SUVmax, SUVmean, NSUVmax, and NSUVmean were consistently observed at C5 and the lowest at T6. Using a 9 mm ROI, the highest values were consistently observed at C5 and the lowest at T12 or T6. The spinal cord [18F]FDG-uptake values correlated with the bone marrow uptake at the same level, especially in case of NSUVmax. Comparison with PET-CT data revealed that the average SUVmax and SUVmean of the spinal cord were similar in PET-MRI and PET-CT. However, the average NSUVmax and NSUVmean of the spinal cord were higher (range 21–47%) in PET-MRI than in PET-CT. Conclusions Using a whole-body protocol, we defined the maximum and mean [18F]FDG uptake of the normal spinal cord in PET/MRI. While the observed values show the expected longitudinal distribution, they appear to be higher than those measured in PET/CT. Normalization of the SUVmax and SUVmean of the spinal cord to the liver radiotracer uptake could help in multi-institutional comparisons and studies. |
topic |
FDG PET/MRI Spinal cord SUV |
url |
http://link.springer.com/article/10.1186/s13550-020-00680-8 |
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