Analysis of MMP2 promoter polymorphisms in childhood obesity

• Main Authors: Thompson John MD, Han Dug, Morgan Angharad R, Mitchell Edwin A, Ferguson Lynnette R
• Format: Article
• Language: English
• Published: BMC 2011-07-01
• Series: BMC Research Notes
• Subjects: childhood obesity; percentage body fat; matrix metalloproteinase-2; genetic association
• Online Access: http://www.biomedcentral.com/1756-0500/4/253

<p>Abstract</p> <p>Background</p> <p>Several lines of evidence suggest a possible functional role of Matrix metalloproteinase -2 (MMP-2) in obesity. The aim of this study was to evaluate the role of MMP-2 promoter polymorphisms in percentage body fat (PBF) as a measure of childhood obesity in a New Zealand population.</p> <p>Findings</p> <p>546 samples from the Auckland Birthweight Collaborative (ABC) study were genotyped for the three MMP-2 promoter SNPs -1306 C/T (rs243865), -1575G/A (rs243866) and -790 T/G (rs243864) using the Sequenom genotyping platform. The results demonstrated that an MMP-2 promoter haplotype is associated with PBF in New Zealand 7 year old children.</p> <p>Conclusion</p> <p>We have previously determined that environmental factors are associated with differences in PBF in this study group, and now we have demonstrated a possible genetic contribution.</p>