Androgen receptor variant shows heterogeneous expression in prostate cancer according to differentiation stage
Ada Gjyrezi et al. show that ddPCR can be used to accurately measure androgen receptor variant (AR-V) expression levels in single circulating tumor cells (CTCs) from prostate cancer patients. They show that current methods for isolating CTCs tend to underestimate the prevalence of AR-V and that a sp...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-06-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02321-9 |
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doaj-54507da59cc5412fa5d4da9b3a6019562021-06-27T11:27:20ZengNature Publishing GroupCommunications Biology2399-36422021-06-01411910.1038/s42003-021-02321-9Androgen receptor variant shows heterogeneous expression in prostate cancer according to differentiation stageAda Gjyrezi0Giuseppe Galletti1Jiaren Zhang2Daniel Worroll3Michael Sigouros4Seaho Kim5Victoria Cooley6Karla V. Ballman7Allyson J. Ocean8Manish A. Shah9Joseph M. Scandura10Andrea Sboner11David M. Nanus12Himisha Beltran13Scott Tagawa14Paraskevi Giannakakou15Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell MedicineDivision of Hematology and Medical Oncology, Department of Medicine, Weill Cornell MedicineDivision of Hematology and Medical Oncology, Department of Medicine, Weill Cornell MedicineDivision of Hematology and Medical Oncology, Department of Medicine, Weill Cornell MedicineCaryl and Israel Englander Institute for Precision Medicine, Weill Cornell MedicineDivision of Hematology and Medical Oncology, Department of Medicine, Weill Cornell MedicineDepartment of Population Health Sciences, Division of Biostatistics, Weill Cornell MedicineDepartment of Population Health Sciences, Division of Biostatistics, Weill Cornell MedicineDivision of Hematology and Medical Oncology, Department of Medicine, Weill Cornell MedicineDivision of Hematology and Medical Oncology, Department of Medicine, Weill Cornell MedicineRichard T. Silver, M.D. Myeloproliferative Neoplasms Center, Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell MedicineCaryl and Israel Englander Institute for Precision Medicine, Weill Cornell MedicineDivision of Hematology and Medical Oncology, Department of Medicine, Weill Cornell MedicineDana-Farber Cancer InstituteDivision of Hematology and Medical Oncology, Department of Medicine, Weill Cornell MedicineDivision of Hematology and Medical Oncology, Department of Medicine, Weill Cornell MedicineAda Gjyrezi et al. show that ddPCR can be used to accurately measure androgen receptor variant (AR-V) expression levels in single circulating tumor cells (CTCs) from prostate cancer patients. They show that current methods for isolating CTCs tend to underestimate the prevalence of AR-V and that a specific variant, AR-v567es, could be potentially used as a biomarker for an aggressive subtype of prostate cancer.https://doi.org/10.1038/s42003-021-02321-9 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Ada Gjyrezi Giuseppe Galletti Jiaren Zhang Daniel Worroll Michael Sigouros Seaho Kim Victoria Cooley Karla V. Ballman Allyson J. Ocean Manish A. Shah Joseph M. Scandura Andrea Sboner David M. Nanus Himisha Beltran Scott Tagawa Paraskevi Giannakakou |
| spellingShingle |
Ada Gjyrezi Giuseppe Galletti Jiaren Zhang Daniel Worroll Michael Sigouros Seaho Kim Victoria Cooley Karla V. Ballman Allyson J. Ocean Manish A. Shah Joseph M. Scandura Andrea Sboner David M. Nanus Himisha Beltran Scott Tagawa Paraskevi Giannakakou Androgen receptor variant shows heterogeneous expression in prostate cancer according to differentiation stage Communications Biology |
| author_facet |
Ada Gjyrezi Giuseppe Galletti Jiaren Zhang Daniel Worroll Michael Sigouros Seaho Kim Victoria Cooley Karla V. Ballman Allyson J. Ocean Manish A. Shah Joseph M. Scandura Andrea Sboner David M. Nanus Himisha Beltran Scott Tagawa Paraskevi Giannakakou |
| author_sort |
Ada Gjyrezi |
| title |
Androgen receptor variant shows heterogeneous expression in prostate cancer according to differentiation stage |
| title_short |
Androgen receptor variant shows heterogeneous expression in prostate cancer according to differentiation stage |
| title_full |
Androgen receptor variant shows heterogeneous expression in prostate cancer according to differentiation stage |
| title_fullStr |
Androgen receptor variant shows heterogeneous expression in prostate cancer according to differentiation stage |
| title_full_unstemmed |
Androgen receptor variant shows heterogeneous expression in prostate cancer according to differentiation stage |
| title_sort |
androgen receptor variant shows heterogeneous expression in prostate cancer according to differentiation stage |
| publisher |
Nature Publishing Group |
| series |
Communications Biology |
| issn |
2399-3642 |
| publishDate |
2021-06-01 |
| description |
Ada Gjyrezi et al. show that ddPCR can be used to accurately measure androgen receptor variant (AR-V) expression levels in single circulating tumor cells (CTCs) from prostate cancer patients. They show that current methods for isolating CTCs tend to underestimate the prevalence of AR-V and that a specific variant, AR-v567es, could be potentially used as a biomarker for an aggressive subtype of prostate cancer. |
| url |
https://doi.org/10.1038/s42003-021-02321-9 |
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