Impact of Modality and Intensity of Early Exercise Training on Ventricular Remodeling after Myocardial Infarction
The objective of this study was to analyze the impact of different modalities and intensities of exercise training on cardiac remodeling started early after experimental myocardial infarction (MI). Male Wistar rats, weighing 200–250 g, were subjected to experimental MI. After 5 days, the animals wer...
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Series: | Oxidative Medicine and Cellular Longevity |
Online Access: | http://dx.doi.org/10.1155/2020/5041791 |
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doaj-54560fde902a4278a77f3437c0c1021f2020-11-25T02:38:17ZengHindawi LimitedOxidative Medicine and Cellular Longevity1942-09001942-09942020-01-01202010.1155/2020/50417915041791Impact of Modality and Intensity of Early Exercise Training on Ventricular Remodeling after Myocardial InfarctionDiego Fernando Batista0Bertha Furlan Polegato1Renata Candido da Silva2Renan Turini Claro3Paula Shmidt Azevedo4Ana Angélica Fernandes5Katashi Okoshi6Sergio Alberto Rupp de Paiva7Marcos Ferreira Minicucci8Leonardo Antônio Mamede Zornorff9Internal Medicine Department, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, BrazilInternal Medicine Department, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, BrazilInternal Medicine Department, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, BrazilInternal Medicine Department, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, BrazilInternal Medicine Department, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, BrazilChemistry and Biochemistry Department, Institute of Biosciences of Botucatu, São Paulo State University (UNESP), Botucatu, BrazilInternal Medicine Department, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, BrazilInternal Medicine Department, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, BrazilInternal Medicine Department, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, BrazilInternal Medicine Department, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, BrazilThe objective of this study was to analyze the impact of different modalities and intensities of exercise training on cardiac remodeling started early after experimental myocardial infarction (MI). Male Wistar rats, weighing 200–250 g, were subjected to experimental MI. After 5 days, the animals were allocated into three experimental groups and observed for three months: S (sedentary control animals), C (animals subjected to continuous low-intensity training), and HIT (animals subjected to high-intensity interval training). Low-intensity exercise training was performed at a treadmill speed corresponding to 40% VO2 max, which was kept unchanged throughout the entire session (i.e., continuous low-intensity training). High-intensity interval training was performed in such a way that rats run during 3 min at 60% VO2 max, followed by 4-minute intervals at 85% VO2 max (i.e., high-intensity interval training). After the follow-up period, we studied hypertrophy and ventricular geometry, functional alterations in vivo and in vitro, oxidative stress, apoptosis, and cardiac energetic metabolism. Our data showed that both high-intensity interval and continuous low-intensity modalities improved cardiac energetic metabolism variables in comparison with sedentary infarcted animals. In addition, high-intensity interval training decreased cardiac oxidative stress, associated with improved diastolic function. On the other hand, the continuous low-intensity group showed impairment of cardiac function. Therefore, altogether, our data suggest that high-intensity interval training could be the best modality for early physical exercise after MI and should be better studied in this clinical scenario.http://dx.doi.org/10.1155/2020/5041791 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Diego Fernando Batista Bertha Furlan Polegato Renata Candido da Silva Renan Turini Claro Paula Shmidt Azevedo Ana Angélica Fernandes Katashi Okoshi Sergio Alberto Rupp de Paiva Marcos Ferreira Minicucci Leonardo Antônio Mamede Zornorff |
spellingShingle |
Diego Fernando Batista Bertha Furlan Polegato Renata Candido da Silva Renan Turini Claro Paula Shmidt Azevedo Ana Angélica Fernandes Katashi Okoshi Sergio Alberto Rupp de Paiva Marcos Ferreira Minicucci Leonardo Antônio Mamede Zornorff Impact of Modality and Intensity of Early Exercise Training on Ventricular Remodeling after Myocardial Infarction Oxidative Medicine and Cellular Longevity |
author_facet |
Diego Fernando Batista Bertha Furlan Polegato Renata Candido da Silva Renan Turini Claro Paula Shmidt Azevedo Ana Angélica Fernandes Katashi Okoshi Sergio Alberto Rupp de Paiva Marcos Ferreira Minicucci Leonardo Antônio Mamede Zornorff |
author_sort |
Diego Fernando Batista |
title |
Impact of Modality and Intensity of Early Exercise Training on Ventricular Remodeling after Myocardial Infarction |
title_short |
Impact of Modality and Intensity of Early Exercise Training on Ventricular Remodeling after Myocardial Infarction |
title_full |
Impact of Modality and Intensity of Early Exercise Training on Ventricular Remodeling after Myocardial Infarction |
title_fullStr |
Impact of Modality and Intensity of Early Exercise Training on Ventricular Remodeling after Myocardial Infarction |
title_full_unstemmed |
Impact of Modality and Intensity of Early Exercise Training on Ventricular Remodeling after Myocardial Infarction |
title_sort |
impact of modality and intensity of early exercise training on ventricular remodeling after myocardial infarction |
publisher |
Hindawi Limited |
series |
Oxidative Medicine and Cellular Longevity |
issn |
1942-0900 1942-0994 |
publishDate |
2020-01-01 |
description |
The objective of this study was to analyze the impact of different modalities and intensities of exercise training on cardiac remodeling started early after experimental myocardial infarction (MI). Male Wistar rats, weighing 200–250 g, were subjected to experimental MI. After 5 days, the animals were allocated into three experimental groups and observed for three months: S (sedentary control animals), C (animals subjected to continuous low-intensity training), and HIT (animals subjected to high-intensity interval training). Low-intensity exercise training was performed at a treadmill speed corresponding to 40% VO2 max, which was kept unchanged throughout the entire session (i.e., continuous low-intensity training). High-intensity interval training was performed in such a way that rats run during 3 min at 60% VO2 max, followed by 4-minute intervals at 85% VO2 max (i.e., high-intensity interval training). After the follow-up period, we studied hypertrophy and ventricular geometry, functional alterations in vivo and in vitro, oxidative stress, apoptosis, and cardiac energetic metabolism. Our data showed that both high-intensity interval and continuous low-intensity modalities improved cardiac energetic metabolism variables in comparison with sedentary infarcted animals. In addition, high-intensity interval training decreased cardiac oxidative stress, associated with improved diastolic function. On the other hand, the continuous low-intensity group showed impairment of cardiac function. Therefore, altogether, our data suggest that high-intensity interval training could be the best modality for early physical exercise after MI and should be better studied in this clinical scenario. |
url |
http://dx.doi.org/10.1155/2020/5041791 |
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