Design, Synthesis and DNA Interaction Study of New Potential DNA Bis-Intercalators Based on Glucuronic Acid

Design, Synthesis and DNA Interaction Study of New Potential DNA Bis-Intercalators Based on Glucuronic Acid

A series of novel potential DNA bis-intercalators were designed and synthesized, in which two glucuronic acids were linked by ethylenediamine, and the glucuronic acid was coupled with various chromophores, including quinoline, acridine, indole and purine, at the C-1 position. The preliminary binding...

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Bibliographic Details
Main Authors: Jiuyang Zhao, Wei Li, Rui Ma, Shaopeng Chen, Tao Jiang, Sumei Ren
Format: Article
Language:English
Published: MDPI AG 2013-08-01
Series:International Journal of Molecular Sciences
Subjects:
glycuronic acid
DNA bis-intercaltor
synthesis and design
Online Access:http://www.mdpi.com/1422-0067/14/8/16851
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spelling doaj-545946f2484a4416b4b34d09a338c31a2020-11-24T20:54:28ZengMDPI AGInternational Journal of Molecular Sciences1422-00672013-08-01148168511686510.3390/ijms140816851Design, Synthesis and DNA Interaction Study of New Potential DNA Bis-Intercalators Based on Glucuronic AcidJiuyang ZhaoWei LiRui MaShaopeng ChenTao JiangSumei RenA series of novel potential DNA bis-intercalators were designed and synthesized, in which two glucuronic acids were linked by ethylenediamine, and the glucuronic acid was coupled with various chromophores, including quinoline, acridine, indole and purine, at the C-1 position. The preliminary binding properties of these compounds to calf thymus DNA (CT-DNA) have been investigated by UV-absorption and fluorescence spectroscopy. The results indicated that all the target compounds can interact with CT-DNA, and the acridine derivative, 3b, showed the highest key selection vector (KSV) value, which suggested that compound 3b binds most strongly to CT-DNA.http://www.mdpi.com/1422-0067/14/8/16851glycuronic acidDNA bis-intercaltorsynthesis and design
collection DOAJ
language English
format Article
sources DOAJ
author Jiuyang Zhao
Wei Li
Rui Ma
Shaopeng Chen
Tao Jiang
Sumei Ren
spellingShingle Jiuyang Zhao
Wei Li
Rui Ma
Shaopeng Chen
Tao Jiang
Sumei Ren
Design, Synthesis and DNA Interaction Study of New Potential DNA Bis-Intercalators Based on Glucuronic Acid
International Journal of Molecular Sciences
glycuronic acid
DNA bis-intercaltor
synthesis and design
author_facet Jiuyang Zhao
Wei Li
Rui Ma
Shaopeng Chen
Tao Jiang
Sumei Ren
author_sort Jiuyang Zhao
title Design, Synthesis and DNA Interaction Study of New Potential DNA Bis-Intercalators Based on Glucuronic Acid
title_short Design, Synthesis and DNA Interaction Study of New Potential DNA Bis-Intercalators Based on Glucuronic Acid
title_full Design, Synthesis and DNA Interaction Study of New Potential DNA Bis-Intercalators Based on Glucuronic Acid
title_fullStr Design, Synthesis and DNA Interaction Study of New Potential DNA Bis-Intercalators Based on Glucuronic Acid
title_full_unstemmed Design, Synthesis and DNA Interaction Study of New Potential DNA Bis-Intercalators Based on Glucuronic Acid
title_sort design, synthesis and dna interaction study of new potential dna bis-intercalators based on glucuronic acid
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1422-0067
publishDate 2013-08-01
description A series of novel potential DNA bis-intercalators were designed and synthesized, in which two glucuronic acids were linked by ethylenediamine, and the glucuronic acid was coupled with various chromophores, including quinoline, acridine, indole and purine, at the C-1 position. The preliminary binding properties of these compounds to calf thymus DNA (CT-DNA) have been investigated by UV-absorption and fluorescence spectroscopy. The results indicated that all the target compounds can interact with CT-DNA, and the acridine derivative, 3b, showed the highest key selection vector (KSV) value, which suggested that compound 3b binds most strongly to CT-DNA.
topic glycuronic acid
DNA bis-intercaltor
synthesis and design
url http://www.mdpi.com/1422-0067/14/8/16851
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AT ruima designsynthesisanddnainteractionstudyofnewpotentialdnabisintercalatorsbasedonglucuronicacid
AT shaopengchen designsynthesisanddnainteractionstudyofnewpotentialdnabisintercalatorsbasedonglucuronicacid
AT taojiang designsynthesisanddnainteractionstudyofnewpotentialdnabisintercalatorsbasedonglucuronicacid
AT sumeiren designsynthesisanddnainteractionstudyofnewpotentialdnabisintercalatorsbasedonglucuronicacid
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