Design, Synthesis and DNA Interaction Study of New Potential DNA Bis-Intercalators Based on Glucuronic Acid
A series of novel potential DNA bis-intercalators were designed and synthesized, in which two glucuronic acids were linked by ethylenediamine, and the glucuronic acid was coupled with various chromophores, including quinoline, acridine, indole and purine, at the C-1 position. The preliminary binding...
Main Authors: | Jiuyang Zhao, Wei Li, Rui Ma, Shaopeng Chen, Tao Jiang, Sumei Ren |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2013-08-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | http://www.mdpi.com/1422-0067/14/8/16851 |
Similar Items
-
Novel DNA Bis-Intercalator XR5944 as a Potent Anticancer Drug—Design and Mechanism of Action
by: Adam J. Buric, et al.
Published: (2021-07-01) -
Synthesis, DNA Binding, and Anticancer Properties of Bis-Naphthalimide Derivatives with Lysine-Modified Polyamine Linkers
by: Yu Huang, et al.
Published: (2018-01-01) -
Truncated azinomycin analogues intercalate into DNA.
by: Casely-Hayford, M.A., et al.
Published: (2009) -
Synthesis of Acridine-based DNA Bis-intercalating Agents
by: P. Mack, et al.
Published: (2001-02-01) -
Rational Design and Synthesis of Naphthalene Diimide Linked Bis-Naphthalimides as DNA Interactive Agents
by: M. Shaheer Malik, et al.
Published: (2021-03-01)