Effectiveness of Cherries in Reducing Uric Acid and Gout: A Systematic Review
Background. Previous studies have reported the use of complementary therapies to reduce the risk of gout attacks. In this study, we assessed the effectiveness of cherries in reducing uric acid levels associated with gout. Methods. We searched for relevant studies on PubMed, Embase, and the Cochrane...
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doaj-546a8794815a415691ee233660bdb18e2020-11-25T01:42:37ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882019-01-01201910.1155/2019/98967579896757Effectiveness of Cherries in Reducing Uric Acid and Gout: A Systematic ReviewPei-En Chen0Chia-Yu Liu1Wu-Hsiung Chien2Ching-Wen Chien3Tao-Hsin Tung4Hechi Third People’s Hospital, Hechi City, Guangxi, ChinaSchool of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei, TaiwanDepartment of Family and Community Medicine, Cheng-Hsin General Hospital, Taipei, TaiwanInstitute for Hospital Management, Tsing Hua University, Shenzhen Campus, ChinaHechi Third People’s Hospital, Hechi City, Guangxi, ChinaBackground. Previous studies have reported the use of complementary therapies to reduce the risk of gout attacks. In this study, we assessed the effectiveness of cherries in reducing uric acid levels associated with gout. Methods. We searched for relevant studies on PubMed, Embase, and the Cochrane Library without restrictions on language from inception until August 15, 2019. The risk of bias was evaluated using the PRISMA statement and checklist, and the methodological quality was assessed using the Cochrane Collaboration tool. Results. The six studies included in this systematic review reported decreases in the incidence and severity of gout following the ingestion of cherries. Gout patients regularly ingesting cherry extract/juice reported fewer gout flare ups than those patients who did not supplement their diets with cherry products. Overall, we observed a positive correlation between the consumption of tart cherry juice and a decrease in serum uric acid concentration. Conclusions. Current evidence supports an association between cherry intake and a reduced risk of gout attacks. Note however that we were unable to conduct effective meta-analysis due to a lack of relevant studies and a high degree of variation in the methodologies and metrics used in previous studies. Further comprehensive trials or long-term follow-up studies will be required to evaluate the efficacy of cherry intake in treating patients with gout or hyperuricemia.http://dx.doi.org/10.1155/2019/9896757 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pei-En Chen Chia-Yu Liu Wu-Hsiung Chien Ching-Wen Chien Tao-Hsin Tung |
spellingShingle |
Pei-En Chen Chia-Yu Liu Wu-Hsiung Chien Ching-Wen Chien Tao-Hsin Tung Effectiveness of Cherries in Reducing Uric Acid and Gout: A Systematic Review Evidence-Based Complementary and Alternative Medicine |
author_facet |
Pei-En Chen Chia-Yu Liu Wu-Hsiung Chien Ching-Wen Chien Tao-Hsin Tung |
author_sort |
Pei-En Chen |
title |
Effectiveness of Cherries in Reducing Uric Acid and Gout: A Systematic Review |
title_short |
Effectiveness of Cherries in Reducing Uric Acid and Gout: A Systematic Review |
title_full |
Effectiveness of Cherries in Reducing Uric Acid and Gout: A Systematic Review |
title_fullStr |
Effectiveness of Cherries in Reducing Uric Acid and Gout: A Systematic Review |
title_full_unstemmed |
Effectiveness of Cherries in Reducing Uric Acid and Gout: A Systematic Review |
title_sort |
effectiveness of cherries in reducing uric acid and gout: a systematic review |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-427X 1741-4288 |
publishDate |
2019-01-01 |
description |
Background. Previous studies have reported the use of complementary therapies to reduce the risk of gout attacks. In this study, we assessed the effectiveness of cherries in reducing uric acid levels associated with gout. Methods. We searched for relevant studies on PubMed, Embase, and the Cochrane Library without restrictions on language from inception until August 15, 2019. The risk of bias was evaluated using the PRISMA statement and checklist, and the methodological quality was assessed using the Cochrane Collaboration tool. Results. The six studies included in this systematic review reported decreases in the incidence and severity of gout following the ingestion of cherries. Gout patients regularly ingesting cherry extract/juice reported fewer gout flare ups than those patients who did not supplement their diets with cherry products. Overall, we observed a positive correlation between the consumption of tart cherry juice and a decrease in serum uric acid concentration. Conclusions. Current evidence supports an association between cherry intake and a reduced risk of gout attacks. Note however that we were unable to conduct effective meta-analysis due to a lack of relevant studies and a high degree of variation in the methodologies and metrics used in previous studies. Further comprehensive trials or long-term follow-up studies will be required to evaluate the efficacy of cherry intake in treating patients with gout or hyperuricemia. |
url |
http://dx.doi.org/10.1155/2019/9896757 |
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