The double-sided effects of Mycobacterium Bovis bacillus Calmette–Guérin vaccine

The double-sided effects of Mycobacterium Bovis bacillus Calmette–Guérin vaccine

Abstract Bacillus Calmette–Guérin (BCG), the only vaccine proven to be effective against tuberculosis (TB), is the most commonly used vaccine globally. In addition to its effects on mycobacterial diseases, an increasing amount of epidemiological and experimental evidence accumulated since its introd...

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Main Authors: Junli Li, Lingjun Zhan, Chuan Qin
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-020-00278-0
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spelling doaj-546de3daadba442da33539035d701e322021-01-31T16:19:35ZengNature Publishing Groupnpj Vaccines2059-01052021-01-016111110.1038/s41541-020-00278-0The double-sided effects of Mycobacterium Bovis bacillus Calmette–Guérin vaccineJunli Li0Lingjun Zhan1Chuan Qin2NHC Key Laboratory of Human Disease Comparative Medicine, Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)NHC Key Laboratory of Human Disease Comparative Medicine, Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)NHC Key Laboratory of Human Disease Comparative Medicine, Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)Abstract Bacillus Calmette–Guérin (BCG), the only vaccine proven to be effective against tuberculosis (TB), is the most commonly used vaccine globally. In addition to its effects on mycobacterial diseases, an increasing amount of epidemiological and experimental evidence accumulated since its introduction in 1921 has shown that BCG also exerts non-specific effects against a number of diseases, such as non-mycobacterial infections, allergies and certain malignancies. Recent Corona Virus Disease 2019 (COVID-19) outbreak has put BCG, a classic vaccine with significant non-specific protection, into the spotlight again. This literature review briefly covers the diverse facets of BCG vaccine, providing new perspectives in terms of specific and non-specific protection mechanisms of this old, multifaceted, and controversial vaccine.https://doi.org/10.1038/s41541-020-00278-0
collection DOAJ
language English
format Article
sources DOAJ
author Junli Li
Lingjun Zhan
Chuan Qin
spellingShingle Junli Li
Lingjun Zhan
Chuan Qin
The double-sided effects of Mycobacterium Bovis bacillus Calmette–Guérin vaccine
npj Vaccines
author_facet Junli Li
Lingjun Zhan
Chuan Qin
author_sort Junli Li
title The double-sided effects of Mycobacterium Bovis bacillus Calmette–Guérin vaccine
title_short The double-sided effects of Mycobacterium Bovis bacillus Calmette–Guérin vaccine
title_full The double-sided effects of Mycobacterium Bovis bacillus Calmette–Guérin vaccine
title_fullStr The double-sided effects of Mycobacterium Bovis bacillus Calmette–Guérin vaccine
title_full_unstemmed The double-sided effects of Mycobacterium Bovis bacillus Calmette–Guérin vaccine
title_sort double-sided effects of mycobacterium bovis bacillus calmette–guérin vaccine
publisher Nature Publishing Group
series npj Vaccines
issn 2059-0105
publishDate 2021-01-01
description Abstract Bacillus Calmette–Guérin (BCG), the only vaccine proven to be effective against tuberculosis (TB), is the most commonly used vaccine globally. In addition to its effects on mycobacterial diseases, an increasing amount of epidemiological and experimental evidence accumulated since its introduction in 1921 has shown that BCG also exerts non-specific effects against a number of diseases, such as non-mycobacterial infections, allergies and certain malignancies. Recent Corona Virus Disease 2019 (COVID-19) outbreak has put BCG, a classic vaccine with significant non-specific protection, into the spotlight again. This literature review briefly covers the diverse facets of BCG vaccine, providing new perspectives in terms of specific and non-specific protection mechanisms of this old, multifaceted, and controversial vaccine.
url https://doi.org/10.1038/s41541-020-00278-0
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