L-Asparaginase Isolated from Phaseolus vulgaris Seeds Exhibited Potent Anti-Acute Lymphoblastic Leukemia Effects In-Vitro and Low Immunogenic Properties In-Vivo

L-Asparaginase Isolated from Phaseolus vulgaris Seeds Exhibited Potent Anti-Acute Lymphoblastic Leukemia Effects In-Vitro and Low Immunogenic Properties In-Vivo

Escherichia coli-derived L-asparaginases have been used in the treatment of acute lymphoblastic leukemia (ALL), however, clinical hypersensitivity reactions and silent inactivation due to antibodies against E. coli-asparaginase, lead to inactivation of these preparations in most cases.Therefore, thi...

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Bibliographic Details
Main Authors: Saleh A. Mohamed, Mohamed F. Elshal, Taha A. Kumosani, Alia M. Aldahlawi, Tasneem A. Basbrain, Fauziah A. Alshehri, Hani Choudhry
Format: Article
Language:English
Published: MDPI AG 2016-10-01
Series:International Journal of Environmental Research and Public Health
Subjects:
asparaginase
acute lymphoplastic leukemia
allergy
Immunogenicity
proliferation
apoptosis
cytotoxicity
Online Access:http://www.mdpi.com/1660-4601/13/10/1008

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