Effect of proline analogues on activity of human prolyl hydroxylase and the regulation of HIF signal transduction pathway.
Hypoxia inducible factor 1 (HIF-1) plays a pivotal role in cellular responses to hypoxia. Prolyl hydroxylase 3 (PHD3) degrades HIF-1α under normoxic conditions through the hydroxylation of HIF-1α for proteolysis. Inhibiting PHD3 activity is crucial for up-regulating HIF-1α, thereby acting as a poten...
Main Authors: | Xiaoyan Ma, Xiaoxin Wang, Jing Cao, Zhirong Geng, Zhilin Wang |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-01-01
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Series: | PLoS ONE |
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24755992/?tool=EBI |
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