Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice

Beta cell dysfunction and reduction in beta cell mass are hallmark events in the pathogenesis of diabetes mellitus. We identify focal adhesion protein Kindlin-2 as a key factor that controls insulin synthesis and secretion and beta cell mass by modulating MafA and beta-catenin proteins in pancreatic...

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Main Authors:	Ke Zhu, Yumei Lai, Huiling Cao, Xiaochun Bai, Chuanju Liu, Qinnan Yan, Liting Ma, Di Chen, Giedrius Kanaporis, Junqi Wang, Luyuan Li, Tao Cheng, Yong Wang, Chuanyue Wu, Guozhi Xiao
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-14186-y

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spelling	doaj-548e9c8e7d274d1f95a9ccdc09d4cf7f2021-05-11T08:06:42ZengNature Publishing GroupNature Communications2041-17232020-01-0111111510.1038/s41467-019-14186-yKindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in miceKe Zhu0Yumei Lai1Huiling Cao2Xiaochun Bai3Chuanju Liu4Qinnan Yan5Liting Ma6Di Chen7Giedrius Kanaporis8Junqi Wang9Luyuan Li10Tao Cheng11Yong Wang12Chuanyue Wu13Guozhi Xiao14Department of Orthopedic Surgery, Rush University Medical CenterDepartment of Orthopedic Surgery, Rush University Medical CenterGuangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, and Department of Biology, Southern University of Science and TechnologyDepartment of Cell Biology, School of Basic Medical Sciences, Southern Medical UniversityDepartment of Orthopedic Surgery, New York University School of MedicineGuangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, and Department of Biology, Southern University of Science and TechnologyGuangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, and Department of Biology, Southern University of Science and TechnologyDepartment of Orthopedic Surgery, Rush University Medical CenterDepartment of Molecular Biophysics and Physiology, Rush University Medical CenterGuangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, and Department of Biology, Southern University of Science and TechnologyState Key Laboratory of Medicinal Chemical Biology and Nankai University College of PharmacyState Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Center for Stem Cell Medicine, Chinese Academy of Medical Sciences & Peking Union Medical CollegeUVA Islet Microfluidic Laboratory, Department of Surgery, the University of VirginiaDepartment of Pathology, University of PittsburghGuangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, and Department of Biology, Southern University of Science and TechnologyBeta cell dysfunction and reduction in beta cell mass are hallmark events in the pathogenesis of diabetes mellitus. We identify focal adhesion protein Kindlin-2 as a key factor that controls insulin synthesis and secretion and beta cell mass by modulating MafA and beta-catenin proteins in pancreatic beta cells.https://doi.org/10.1038/s41467-019-14186-y
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ke Zhu Yumei Lai Huiling Cao Xiaochun Bai Chuanju Liu Qinnan Yan Liting Ma Di Chen Giedrius Kanaporis Junqi Wang Luyuan Li Tao Cheng Yong Wang Chuanyue Wu Guozhi Xiao
spellingShingle	Ke Zhu Yumei Lai Huiling Cao Xiaochun Bai Chuanju Liu Qinnan Yan Liting Ma Di Chen Giedrius Kanaporis Junqi Wang Luyuan Li Tao Cheng Yong Wang Chuanyue Wu Guozhi Xiao Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice Nature Communications
author_facet	Ke Zhu Yumei Lai Huiling Cao Xiaochun Bai Chuanju Liu Qinnan Yan Liting Ma Di Chen Giedrius Kanaporis Junqi Wang Luyuan Li Tao Cheng Yong Wang Chuanyue Wu Guozhi Xiao
author_sort	Ke Zhu
title	Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice
title_short	Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice
title_full	Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice
title_fullStr	Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice
title_full_unstemmed	Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice
title_sort	kindlin-2 modulates mafa and β-catenin expression to regulate β-cell function and mass in mice
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-01-01
description	Beta cell dysfunction and reduction in beta cell mass are hallmark events in the pathogenesis of diabetes mellitus. We identify focal adhesion protein Kindlin-2 as a key factor that controls insulin synthesis and secretion and beta cell mass by modulating MafA and beta-catenin proteins in pancreatic beta cells.
url	https://doi.org/10.1038/s41467-019-14186-y
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Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice

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