A Stimulation Function of Synaptotagmin-1 in Ternary SNARE Complex Formation Dependent on Munc18 and Munc13

A Stimulation Function of Synaptotagmin-1 in Ternary SNARE Complex Formation Dependent on Munc18 and Munc13

The Ca2+ sensor synaptotagmin-1 (Syt1) plays an essential function in synaptic exocytosis. Recently, Syt1 has been implicated in synaptic vesicle priming, a maturation step prior to Ca2+-triggered membrane fusion that is believed to involve formation of the ternary SNARE complex and require priming...

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Bibliographic Details
Main Authors: Yun Li, Shen Wang, Tianzhi Li, Le Zhu, Yuanyuan Xu, Cong Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
synaptotagmin-1
SNARE complex
synaptic exocytosis
membrane traffic
synaptic vesicle priming
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00256/full

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