The role of apoptosis in autoantibody production
In normal conditions, the intracellular autoantigens reach the cell surface by apoptosis and are normally cleared by phagocytes without inflammation, nevertheless the lack of depuration of apoptotic material foster the autoantibody production in individuals genetically predisposed, equally defects i...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2011-09-01
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| Series: | Reumatismo |
| Online Access: | http://www.reumatismo.org/index.php/reuma/article/view/316 |
| Summary: | In normal conditions, the intracellular autoantigens reach the cell surface by apoptosis and are normally cleared by phagocytes without inflammation, nevertheless the lack of depuration of apoptotic material foster the autoantibody production in individuals genetically predisposed, equally defects in signaling, execution and malfunction of the apoptotic pathways may induce autoimmunity, in consequence apoptosis is another way of understanding the autoimmunity (1)... |
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| ISSN: | 0048-7449 2240-2683 |