Polymorphisms of HLA-DM on Treatment Response to Interferon/Ribavirin in Patients with Chronic Hepatitis C Virus Type 1 Infection
Background: HLA-DM gene, which is related to antigen processing and presentation and located in the non-classical class-II region of human leukocyte antigen (HLA) region, may play a crucial role in chronic hepatitis C virus (HCV) infection treatment outcomes. The study was conducted to evaluate the...
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doaj-54a125087f974911bee7e28ce49abf1d2020-11-24T23:07:37ZengMDPI AGInternational Journal of Environmental Research and Public Health1660-46012016-10-011310103010.3390/ijerph13101030ijerph13101030Polymorphisms of HLA-DM on Treatment Response to Interferon/Ribavirin in Patients with Chronic Hepatitis C Virus Type 1 InfectionHongbo Chen0Yinan Yao1Yifan Wang2Hua Zhou3Tianxiang Xu4Jing Liu5Guocheng Wang6Yongfeng Zhang7Xiang Chen8Qingwei Liu9Peng Huang10Rongbin Yu11Department of Infectious Disease, the Jurong People’s Hospital, Jurong 212400, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, ChinaDepartment of Infectious Disease, the Jurong People’s Hospital, Jurong 212400, ChinaDepartment of Infectious Disease, the Jurong People’s Hospital, Jurong 212400, ChinaDepartment of Infectious Disease, the Jurong People’s Hospital, Jurong 212400, ChinaDepartment of Infectious Disease, the Jurong People’s Hospital, Jurong 212400, ChinaDepartment of Infectious Disease, the Jurong People’s Hospital, Jurong 212400, ChinaDepartment of Infectious Disease, the Jurong People’s Hospital, Jurong 212400, ChinaDepartment of Infectious Disease, the Jurong People’s Hospital, Jurong 212400, ChinaDepartment of Infectious Disease, the Jurong People’s Hospital, Jurong 212400, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, ChinaBackground: HLA-DM gene, which is related to antigen processing and presentation and located in the non-classical class-II region of human leukocyte antigen (HLA) region, may play a crucial role in chronic hepatitis C virus (HCV) infection treatment outcomes. The study was conducted to evaluate the role of the variant of several single nucleotide polymorphisms (SNPs) in HLA-DM gene in HCV treatment outcomes. Methods: We genotyped four SNPs from the candidate genes (HLA-DMA and DMB) in 336 patients who were treated with pegylated interferon-alpha and ribavirin (PEG IFN-α/RBV). Multivariate analysis of factors predicting sustained virological response (SVR) was conducted. Results: HLA-DMA rs1063478 and DMB rs23544 were independent factors of HCV treatment outcomes in Chinese Han population. Individuals who carried favorable genotypes of rs1063478TT and rs23544GG were more likely to achieve SVR {Dominant model: odds ratio (OR) = 2.05, 95% confidence interval (CI) = 1.24–3.41; OR = 2.04, 95% CI =1.23–3.35, respectively}. Rs23544, rs1063478, baseline glucose, baseline platelet and T4 level were independent predictors of SVR. The area under the receiver operating characteristic (ROC) curve (AUC) was 0.740. Conclusions: The genetic variation of rs1063478 and rs23544 are associated with the treatment outcomes in the Chinese Han population.http://www.mdpi.com/1660-4601/13/10/1030hepatitis Cgenetic polymorphismHLA-DM genetreatment outcome |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hongbo Chen Yinan Yao Yifan Wang Hua Zhou Tianxiang Xu Jing Liu Guocheng Wang Yongfeng Zhang Xiang Chen Qingwei Liu Peng Huang Rongbin Yu |
spellingShingle |
Hongbo Chen Yinan Yao Yifan Wang Hua Zhou Tianxiang Xu Jing Liu Guocheng Wang Yongfeng Zhang Xiang Chen Qingwei Liu Peng Huang Rongbin Yu Polymorphisms of HLA-DM on Treatment Response to Interferon/Ribavirin in Patients with Chronic Hepatitis C Virus Type 1 Infection International Journal of Environmental Research and Public Health hepatitis C genetic polymorphism HLA-DM gene treatment outcome |
author_facet |
Hongbo Chen Yinan Yao Yifan Wang Hua Zhou Tianxiang Xu Jing Liu Guocheng Wang Yongfeng Zhang Xiang Chen Qingwei Liu Peng Huang Rongbin Yu |
author_sort |
Hongbo Chen |
title |
Polymorphisms of HLA-DM on Treatment Response to Interferon/Ribavirin in Patients with Chronic Hepatitis C Virus Type 1 Infection |
title_short |
Polymorphisms of HLA-DM on Treatment Response to Interferon/Ribavirin in Patients with Chronic Hepatitis C Virus Type 1 Infection |
title_full |
Polymorphisms of HLA-DM on Treatment Response to Interferon/Ribavirin in Patients with Chronic Hepatitis C Virus Type 1 Infection |
title_fullStr |
Polymorphisms of HLA-DM on Treatment Response to Interferon/Ribavirin in Patients with Chronic Hepatitis C Virus Type 1 Infection |
title_full_unstemmed |
Polymorphisms of HLA-DM on Treatment Response to Interferon/Ribavirin in Patients with Chronic Hepatitis C Virus Type 1 Infection |
title_sort |
polymorphisms of hla-dm on treatment response to interferon/ribavirin in patients with chronic hepatitis c virus type 1 infection |
publisher |
MDPI AG |
series |
International Journal of Environmental Research and Public Health |
issn |
1660-4601 |
publishDate |
2016-10-01 |
description |
Background: HLA-DM gene, which is related to antigen processing and presentation and located in the non-classical class-II region of human leukocyte antigen (HLA) region, may play a crucial role in chronic hepatitis C virus (HCV) infection treatment outcomes. The study was conducted to evaluate the role of the variant of several single nucleotide polymorphisms (SNPs) in HLA-DM gene in HCV treatment outcomes. Methods: We genotyped four SNPs from the candidate genes (HLA-DMA and DMB) in 336 patients who were treated with pegylated interferon-alpha and ribavirin (PEG IFN-α/RBV). Multivariate analysis of factors predicting sustained virological response (SVR) was conducted. Results: HLA-DMA rs1063478 and DMB rs23544 were independent factors of HCV treatment outcomes in Chinese Han population. Individuals who carried favorable genotypes of rs1063478TT and rs23544GG were more likely to achieve SVR {Dominant model: odds ratio (OR) = 2.05, 95% confidence interval (CI) = 1.24–3.41; OR = 2.04, 95% CI =1.23–3.35, respectively}. Rs23544, rs1063478, baseline glucose, baseline platelet and T4 level were independent predictors of SVR. The area under the receiver operating characteristic (ROC) curve (AUC) was 0.740. Conclusions: The genetic variation of rs1063478 and rs23544 are associated with the treatment outcomes in the Chinese Han population. |
topic |
hepatitis C genetic polymorphism HLA-DM gene treatment outcome |
url |
http://www.mdpi.com/1660-4601/13/10/1030 |
work_keys_str_mv |
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