LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat

LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat

Brown adipose tissue (BAT) thermogenesis counteracts obesity and promotes metabolic health. The role of long non-coding RNAs (lncRNAs) in the regulation of this process is not well understood. Here the authors identify a maternally expressed lncRNA, H19, that increases BAT oxidative metabolism and e...

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Main Authors: Elena Schmidt, Ines Dhaouadi, Isabella Gaziano, Matteo Oliverio, Paul Klemm, Motoharu Awazawa, Gerfried Mitterer, Eduardo Fernandez-Rebollo, Marta Pradas-Juni, Wolfgang Wagner, Philipp Hammerschmidt, Rute Loureiro, Christoph Kiefer, Nils R. Hansmeier, Sajjad Khani, Matteo Bergami, Markus Heine, Evgenia Ntini, Peter Frommolt, Peter Zentis, Ulf Andersson Ørom, Jörg Heeren, Matthias Blüher, Martin Bilban, Jan-Wilhelm Kornfeld
Format: Article
Language:English
Published: Nature Publishing Group 2018-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05933-8
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spelling doaj-54a402f6076e4b0fbbecca1070ed468d2021-05-11T09:29:45ZengNature Publishing GroupNature Communications2041-17232018-09-019111610.1038/s41467-018-05933-8LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fatElena Schmidt0Ines Dhaouadi1Isabella Gaziano2Matteo Oliverio3Paul Klemm4Motoharu Awazawa5Gerfried Mitterer6Eduardo Fernandez-Rebollo7Marta Pradas-Juni8Wolfgang Wagner9Philipp Hammerschmidt10Rute Loureiro11Christoph Kiefer12Nils R. Hansmeier13Sajjad Khani14Matteo Bergami15Markus Heine16Evgenia Ntini17Peter Frommolt18Peter Zentis19Ulf Andersson Ørom20Jörg Heeren21Matthias Blüher22Martin Bilban23Jan-Wilhelm Kornfeld24Max Planck Institute for Metabolism ResearchMax Planck Institute for Metabolism ResearchMax Planck Institute for Metabolism ResearchMax Planck Institute for Metabolism ResearchMax Planck Institute for Metabolism ResearchMax Planck Institute for Metabolism ResearchDepartment of Laboratory Medicine, Medical University of ViennaDepartment for Biochemistry and Molecular Biology (BMB), University of Southern DenmarkMax Planck Institute for Metabolism ResearchHelmholtz-Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, RWTH Aachen University Medical SchoolMax Planck Institute for Metabolism ResearchMax Planck Institute for Metabolism ResearchDepartment for Biochemistry and Molecular Biology (BMB), University of Southern DenmarkMax Planck Institute for Metabolism ResearchMax Planck Institute for Metabolism ResearchCologne Cluster of Excellence: Cellular Stress Responses in Ageing-associated Diseases (CECAD)Institute for Biochemistry and Molecular Cell BiologyMax Planck Institute for Molecular GeneticsCologne Cluster of Excellence: Cellular Stress Responses in Ageing-associated Diseases (CECAD)Cologne Cluster of Excellence: Cellular Stress Responses in Ageing-associated Diseases (CECAD)Institute for Molecular Biology and Genetics, Aarhus UniversityInstitute for Biochemistry and Molecular Cell BiologyDepartment of Medicine, University of LeipzigDepartment of Laboratory Medicine, Medical University of ViennaMax Planck Institute for Metabolism ResearchBrown adipose tissue (BAT) thermogenesis counteracts obesity and promotes metabolic health. The role of long non-coding RNAs (lncRNAs) in the regulation of this process is not well understood. Here the authors identify a maternally expressed lncRNA, H19, that increases BAT oxidative metabolism and energy expenditure.https://doi.org/10.1038/s41467-018-05933-8
collection DOAJ
language English
format Article
sources DOAJ
author Elena Schmidt
Ines Dhaouadi
Isabella Gaziano
Matteo Oliverio
Paul Klemm
Motoharu Awazawa
Gerfried Mitterer
Eduardo Fernandez-Rebollo
Marta Pradas-Juni
Wolfgang Wagner
Philipp Hammerschmidt
Rute Loureiro
Christoph Kiefer
Nils R. Hansmeier
Sajjad Khani
Matteo Bergami
Markus Heine
Evgenia Ntini
Peter Frommolt
Peter Zentis
Ulf Andersson Ørom
Jörg Heeren
Matthias Blüher
Martin Bilban
Jan-Wilhelm Kornfeld
spellingShingle Elena Schmidt
Ines Dhaouadi
Isabella Gaziano
Matteo Oliverio
Paul Klemm
Motoharu Awazawa
Gerfried Mitterer
Eduardo Fernandez-Rebollo
Marta Pradas-Juni
Wolfgang Wagner
Philipp Hammerschmidt
Rute Loureiro
Christoph Kiefer
Nils R. Hansmeier
Sajjad Khani
Matteo Bergami
Markus Heine
Evgenia Ntini
Peter Frommolt
Peter Zentis
Ulf Andersson Ørom
Jörg Heeren
Matthias Blüher
Martin Bilban
Jan-Wilhelm Kornfeld
LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat
Nature Communications
author_facet Elena Schmidt
Ines Dhaouadi
Isabella Gaziano
Matteo Oliverio
Paul Klemm
Motoharu Awazawa
Gerfried Mitterer
Eduardo Fernandez-Rebollo
Marta Pradas-Juni
Wolfgang Wagner
Philipp Hammerschmidt
Rute Loureiro
Christoph Kiefer
Nils R. Hansmeier
Sajjad Khani
Matteo Bergami
Markus Heine
Evgenia Ntini
Peter Frommolt
Peter Zentis
Ulf Andersson Ørom
Jörg Heeren
Matthias Blüher
Martin Bilban
Jan-Wilhelm Kornfeld
author_sort Elena Schmidt
title LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat
title_short LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat
title_full LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat
title_fullStr LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat
title_full_unstemmed LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat
title_sort lincrna h19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-09-01
description Brown adipose tissue (BAT) thermogenesis counteracts obesity and promotes metabolic health. The role of long non-coding RNAs (lncRNAs) in the regulation of this process is not well understood. Here the authors identify a maternally expressed lncRNA, H19, that increases BAT oxidative metabolism and energy expenditure.
url https://doi.org/10.1038/s41467-018-05933-8
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