Erroneous energy-generating cycles in published genome scale metabolic networks: Identification and removal.
Energy metabolism is central to cellular biology. Thus, genome-scale models of heterotrophic unicellular species must account appropriately for the utilization of external nutrients to synthesize energy metabolites such as ATP. However, metabolic models designed for flux-balance analysis (FBA) may c...
Main Authors: | Claus Jonathan Fritzemeier, Daniel Hartleb, Balázs Szappanos, Balázs Papp, Martin J Lercher |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2017-04-01
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Series: | PLoS Computational Biology |
Online Access: | http://europepmc.org/articles/PMC5413070?pdf=render |
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