Development of Neutralizing and Non-neutralizing Antibodies Targeting Known and Novel Epitopes of TcdB of Clostridioides difficile

Development of Neutralizing and Non-neutralizing Antibodies Targeting Known and Novel Epitopes of TcdB of Clostridioides difficile

Clostridioides difficile is the causative bacterium in 15–20% of all antibiotic associated diarrheas. The symptoms associated with C. difficile infection (CDI) are primarily induced by the two large exotoxins TcdA and TcdB. Both toxins enter target cells by receptor-mediated endocytosis. Although di...

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Bibliographic Details
Main Authors: Viola Fühner, Philip Alexander Heine, Saskia Helmsing, Sebastian Goy, Jasmin Heidepriem, Felix F. Loeffler, Stefan Dübel, Ralf Gerhard, Michael Hust
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Microbiology
Subjects:
Toxin B (TcdB)
Clostridioides difficile
antibody phage display
recombinant antibody
epitope mapping
neutralization
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.02908/full

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