Selection of control, randomization, blinding, and allocation concealment
Clinical trials looking at which treatment is better must have certain checks in place. Appropriate “control” selection while comparing the investigating agent to the “control group is essential to rule out selection bias. Randomization is another step to minimize variability or “confounders.” By ra...
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2019-01-01
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doaj-54ba59a3a11b4c50abe0b2d27e5bfb9e2020-11-25T02:02:00ZengWolters Kluwer Medknow PublicationsIndian Dermatology Online Journal2229-51782019-01-0110560160510.4103/idoj.IDOJ_149_19Selection of control, randomization, blinding, and allocation concealmentAmrita SilPiyush KumarRajesh KumarNilay Kanti DasClinical trials looking at which treatment is better must have certain checks in place. Appropriate “control” selection while comparing the investigating agent to the “control group is essential to rule out selection bias. Randomization is another step to minimize variability or “confounders.” By randomization, research participants have an equal chance of being selected into any treatment group of the study, generating comparable intervention groups, thereby distributing the confounders. A trial can be “open labeled” or “blinded.” By the process of blinding, we make the participant and/or assessing physician unaware of the treatment he/she is going to receive. Thus, the element of bias which can creep in owing to personal preference or subjective component to the assessment of outcome can be eliminated. Concealment of allocation is done as the participant enters the trial. Concealment secures randomization and prevents “selection bias”.http://www.idoj.in/article.asp?issn=2229-5178;year=2019;volume=10;issue=5;spage=601;epage=605;aulast=SilAllocation concealmentblindingclinical trialcontrolrandomizationSNOSE |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Amrita Sil Piyush Kumar Rajesh Kumar Nilay Kanti Das |
spellingShingle |
Amrita Sil Piyush Kumar Rajesh Kumar Nilay Kanti Das Selection of control, randomization, blinding, and allocation concealment Indian Dermatology Online Journal Allocation concealment blinding clinical trial control randomization SNOSE |
author_facet |
Amrita Sil Piyush Kumar Rajesh Kumar Nilay Kanti Das |
author_sort |
Amrita Sil |
title |
Selection of control, randomization, blinding, and allocation concealment |
title_short |
Selection of control, randomization, blinding, and allocation concealment |
title_full |
Selection of control, randomization, blinding, and allocation concealment |
title_fullStr |
Selection of control, randomization, blinding, and allocation concealment |
title_full_unstemmed |
Selection of control, randomization, blinding, and allocation concealment |
title_sort |
selection of control, randomization, blinding, and allocation concealment |
publisher |
Wolters Kluwer Medknow Publications |
series |
Indian Dermatology Online Journal |
issn |
2229-5178 |
publishDate |
2019-01-01 |
description |
Clinical trials looking at which treatment is better must have certain checks in place. Appropriate “control” selection while comparing the investigating agent to the “control group is essential to rule out selection bias. Randomization is another step to minimize variability or “confounders.” By randomization, research participants have an equal chance of being selected into any treatment group of the study, generating comparable intervention groups, thereby distributing the confounders. A trial can be “open labeled” or “blinded.” By the process of blinding, we make the participant and/or assessing physician unaware of the treatment he/she is going to receive. Thus, the element of bias which can creep in owing to personal preference or subjective component to the assessment of outcome can be eliminated. Concealment of allocation is done as the participant enters the trial. Concealment secures randomization and prevents “selection bias”. |
topic |
Allocation concealment blinding clinical trial control randomization SNOSE |
url |
http://www.idoj.in/article.asp?issn=2229-5178;year=2019;volume=10;issue=5;spage=601;epage=605;aulast=Sil |
work_keys_str_mv |
AT amritasil selectionofcontrolrandomizationblindingandallocationconcealment AT piyushkumar selectionofcontrolrandomizationblindingandallocationconcealment AT rajeshkumar selectionofcontrolrandomizationblindingandallocationconcealment AT nilaykantidas selectionofcontrolrandomizationblindingandallocationconcealment |
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