Differential regulation of myeloid-derived suppressor cells by Candida species
Myeloid-derived suppressor cells (MDSCs) are innate immune cells characterized by their ability to suppress T-cell responses. Recently, we demonstrated that the human-pathogenic fungi Candida albicans and Aspergillus fumigatus induced a distinct subset of neutrophilic MDSCs. To dissect Candida-media...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2016-10-01
|
Series: | Frontiers in Microbiology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01624/full |
id |
doaj-54c28459b0484d59b2277c9249464129 |
---|---|
record_format |
Article |
spelling |
doaj-54c28459b0484d59b2277c92494641292020-11-24T22:55:11ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2016-10-01710.3389/fmicb.2016.01624223249Differential regulation of myeloid-derived suppressor cells by Candida speciesAnurag Singh0Felipe Lelis1Stefanie Braig2Iris Schäfer3Dominik Hartl4Nikolaus Rieber5Nikolaus Rieber6University of TübingenUniversity of TübingenUniversity of TübingenUniversity of TübingenUniversity of TübingenUniversity of TübingenTechnische Universität MünchenMyeloid-derived suppressor cells (MDSCs) are innate immune cells characterized by their ability to suppress T-cell responses. Recently, we demonstrated that the human-pathogenic fungi Candida albicans and Aspergillus fumigatus induced a distinct subset of neutrophilic MDSCs. To dissect Candida-mediated MDSC induction in more depth, we studied the relative efficacy of different pathogenic non-albicans Candida species to induce and functionally modulate neutrophilic MDSCs, including C. glabrata, C. parapsilosis, C. dubliniensis and C. krusei. Our data demonstrate that the extent of MDSC generation is largely dependent on the Candida species with MDSCs induced by C. krusei and C. glabrata showing a higher suppressive activity compared to MDSCs induced by C. albicans. In summary, these studies show that fungal MDSC induction is differentially regulated at the species level and differentially affects effector T-cell responses.http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01624/fullCandidaHost-Pathogen Interactionsmyeloid-derived suppressor cellsdectin-1Dectin-2MDSCs |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Anurag Singh Felipe Lelis Stefanie Braig Iris Schäfer Dominik Hartl Nikolaus Rieber Nikolaus Rieber |
spellingShingle |
Anurag Singh Felipe Lelis Stefanie Braig Iris Schäfer Dominik Hartl Nikolaus Rieber Nikolaus Rieber Differential regulation of myeloid-derived suppressor cells by Candida species Frontiers in Microbiology Candida Host-Pathogen Interactions myeloid-derived suppressor cells dectin-1 Dectin-2 MDSCs |
author_facet |
Anurag Singh Felipe Lelis Stefanie Braig Iris Schäfer Dominik Hartl Nikolaus Rieber Nikolaus Rieber |
author_sort |
Anurag Singh |
title |
Differential regulation of myeloid-derived suppressor cells by Candida species |
title_short |
Differential regulation of myeloid-derived suppressor cells by Candida species |
title_full |
Differential regulation of myeloid-derived suppressor cells by Candida species |
title_fullStr |
Differential regulation of myeloid-derived suppressor cells by Candida species |
title_full_unstemmed |
Differential regulation of myeloid-derived suppressor cells by Candida species |
title_sort |
differential regulation of myeloid-derived suppressor cells by candida species |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Microbiology |
issn |
1664-302X |
publishDate |
2016-10-01 |
description |
Myeloid-derived suppressor cells (MDSCs) are innate immune cells characterized by their ability to suppress T-cell responses. Recently, we demonstrated that the human-pathogenic fungi Candida albicans and Aspergillus fumigatus induced a distinct subset of neutrophilic MDSCs. To dissect Candida-mediated MDSC induction in more depth, we studied the relative efficacy of different pathogenic non-albicans Candida species to induce and functionally modulate neutrophilic MDSCs, including C. glabrata, C. parapsilosis, C. dubliniensis and C. krusei. Our data demonstrate that the extent of MDSC generation is largely dependent on the Candida species with MDSCs induced by C. krusei and C. glabrata showing a higher suppressive activity compared to MDSCs induced by C. albicans. In summary, these studies show that fungal MDSC induction is differentially regulated at the species level and differentially affects effector T-cell responses. |
topic |
Candida Host-Pathogen Interactions myeloid-derived suppressor cells dectin-1 Dectin-2 MDSCs |
url |
http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01624/full |
work_keys_str_mv |
AT anuragsingh differentialregulationofmyeloidderivedsuppressorcellsbycandidaspecies AT felipelelis differentialregulationofmyeloidderivedsuppressorcellsbycandidaspecies AT stefaniebraig differentialregulationofmyeloidderivedsuppressorcellsbycandidaspecies AT irisschafer differentialregulationofmyeloidderivedsuppressorcellsbycandidaspecies AT dominikhartl differentialregulationofmyeloidderivedsuppressorcellsbycandidaspecies AT nikolausrieber differentialregulationofmyeloidderivedsuppressorcellsbycandidaspecies AT nikolausrieber differentialregulationofmyeloidderivedsuppressorcellsbycandidaspecies |
_version_ |
1725657555642875904 |