Dissociation of C-Reactive Protein Localizes and Amplifies Inflammation: Evidence for a Direct Biological Role of C-Reactive Protein and Its Conformational Changes

Dissociation of C-Reactive Protein Localizes and Amplifies Inflammation: Evidence for a Direct Biological Role of C-Reactive Protein and Its Conformational Changes

C-reactive protein (CRP) is a member of the pentraxin superfamily that is widely recognized as a marker of inflammatory reactions and cardiovascular risk in humans. Recently, a growing body of data is emerging, which demonstrates that CRP is not only a marker of inflammation but also acts as a direc...

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Bibliographic Details
Main Authors: James D. McFadyen, Jurij Kiefer, David Braig, Julia Loseff-Silver, Lawrence A. Potempa, Steffen Ulrich Eisenhardt, Karlheinz Peter
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
inflammation
C-reactive protein
cardiovascular diseases
ischemia/reperfusion
Alzheimer disease
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01351/full

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