Netrins and Their Roles in Placental Angiogenesis
Netrins, a family of laminin-related proteins, were originally identified as axonal guidance molecules. Subsequently, netrins were found to modulate various biological processes including morphogenesis, tumorogenesis, adhesion, and, recently, angiogenesis. In human placenta, the most vascularized or...
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doaj-54c8bf9535e947ecae262308bcbe3c522020-11-24T23:37:45ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/901941901941Netrins and Their Roles in Placental AngiogenesisMbarka Dakouane-Giudicelli0Nadia Alfaidy1Philippe de Mazancourt2Université de Versailles Saint Quentin en Yvelines, Unité Pathologie Cellulaire et Génétique (UPCG) UPRES EA24-93, UFR des Sciences de la Santé, 2 avenue de la Source de la Bièvre, 78180 Montigny le Bretonneux, FranceUnité Mixte INSERM-UJF-CEA-CNRS U1036, CEA, 17 rue des Martyrs, 38054 Grenoble, FranceUniversité de Versailles Saint Quentin en Yvelines, Unité Pathologie Cellulaire et Génétique (UPCG) UPRES EA24-93, UFR des Sciences de la Santé, 2 avenue de la Source de la Bièvre, 78180 Montigny le Bretonneux, FranceNetrins, a family of laminin-related proteins, were originally identified as axonal guidance molecules. Subsequently, netrins were found to modulate various biological processes including morphogenesis, tumorogenesis, adhesion, and, recently, angiogenesis. In human placenta, the most vascularized organ, the presence of netrins has also been reported. Recent studies demonstrated the involvement of netrins in the regulation of placental angiogenesis. In this review we focused on the role of netrins in human placental angiogenesis. Among all netrins examined, netrin-4 and netrin-1 have been found to be either pro- or antiangiogenic factors. These opposite effects appear to be related to the endothelial cell phenotype studied and seem also to depend on the receptor type to which netrin binds, that is, the canonical receptor member of the DCC family, the members of the UNC5 family, or the noncanonical receptor members of the integrin family or DSCAM.http://dx.doi.org/10.1155/2014/901941 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mbarka Dakouane-Giudicelli Nadia Alfaidy Philippe de Mazancourt |
spellingShingle |
Mbarka Dakouane-Giudicelli Nadia Alfaidy Philippe de Mazancourt Netrins and Their Roles in Placental Angiogenesis BioMed Research International |
author_facet |
Mbarka Dakouane-Giudicelli Nadia Alfaidy Philippe de Mazancourt |
author_sort |
Mbarka Dakouane-Giudicelli |
title |
Netrins and Their Roles in Placental Angiogenesis |
title_short |
Netrins and Their Roles in Placental Angiogenesis |
title_full |
Netrins and Their Roles in Placental Angiogenesis |
title_fullStr |
Netrins and Their Roles in Placental Angiogenesis |
title_full_unstemmed |
Netrins and Their Roles in Placental Angiogenesis |
title_sort |
netrins and their roles in placental angiogenesis |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2014-01-01 |
description |
Netrins, a family of laminin-related proteins, were originally identified as axonal guidance molecules. Subsequently, netrins were found to modulate various biological processes including morphogenesis, tumorogenesis, adhesion, and, recently, angiogenesis. In human placenta, the most vascularized organ, the presence of netrins has also been reported. Recent studies demonstrated the involvement of netrins in the regulation of placental angiogenesis. In this review we focused on the role of netrins in human placental angiogenesis. Among all netrins examined, netrin-4 and netrin-1 have been found to be either pro- or antiangiogenic factors. These opposite effects appear to be related to the endothelial cell phenotype studied and seem also to depend on the receptor type to which netrin binds, that is, the canonical receptor member of the DCC family, the members of the UNC5 family, or the noncanonical receptor members of the integrin family or DSCAM. |
url |
http://dx.doi.org/10.1155/2014/901941 |
work_keys_str_mv |
AT mbarkadakouanegiudicelli netrinsandtheirrolesinplacentalangiogenesis AT nadiaalfaidy netrinsandtheirrolesinplacentalangiogenesis AT philippedemazancourt netrinsandtheirrolesinplacentalangiogenesis |
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1725519311628402688 |