Current Approaches for Combination Therapy of Cancer: The Role of Immunogenic Cell Death
Cell death resistance is a key feature of tumor cells. One of the main anticancer therapies is increasing the susceptibility of cells to death. Cancer cells have developed a capability of tumor immune escape. Hence, restoring the immunogenicity of cancer cells can be suggested as an effective approa...
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doaj-54d34831bda24143af0ad29bedc6e24f2020-11-25T02:03:40ZengMDPI AGCancers2072-66942020-04-01121047104710.3390/cancers12041047Current Approaches for Combination Therapy of Cancer: The Role of Immunogenic Cell DeathZahra Asadzadeh0Elham Safarzadeh1Sahar Safaei2Ali Baradaran3Ali Mohammadi4Khalil Hajiasgharzadeh5Afshin Derakhshani6Antonella Argentiero7Nicola Silvestris8Behzad Baradaran9Immunology Research Center, Tabriz University of Medical Sciences, Tabriz 5165665811, IranDepartment of Immunology and Microbiology, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil 5618985991, IranImmunology Research Center, Tabriz University of Medical Sciences, Tabriz 5165665811, IranResearch & Development Lab, BSD Robotics, 4500 Brisbane, AustraliaDepartment of Cancer and Inflammation Research, Institute for Molecular Medicine, University of Southern Denmark, 5230 Odense, DenmarkImmunology Research Center, Tabriz University of Medical Sciences, Tabriz 5165665811, IranImmunology Research Center, Tabriz University of Medical Sciences, Tabriz 5165665811, IranIRCCS Istituto Tumori “Giovanni Paolo II” of Bari, 70124 Bari, ItalyIRCCS Istituto Tumori “Giovanni Paolo II” of Bari, 70124 Bari, ItalyImmunology Research Center, Tabriz University of Medical Sciences, Tabriz 5165665811, IranCell death resistance is a key feature of tumor cells. One of the main anticancer therapies is increasing the susceptibility of cells to death. Cancer cells have developed a capability of tumor immune escape. Hence, restoring the immunogenicity of cancer cells can be suggested as an effective approach against cancer. Accumulating evidence proposes that several anticancer agents provoke the release of danger-associated molecular patterns (DAMPs) that are determinants of immunogenicity and stimulate immunogenic cell death (ICD). It has been suggested that ICD inducers are two different types according to their various activities. Here, we review the well-characterized DAMPs and focus on the different types of ICD inducers and recent combination therapies that can augment the immunogenicity of cancer cells.https://www.mdpi.com/2072-6694/12/4/1047immunogenic cell deathDAMPscombination therapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zahra Asadzadeh Elham Safarzadeh Sahar Safaei Ali Baradaran Ali Mohammadi Khalil Hajiasgharzadeh Afshin Derakhshani Antonella Argentiero Nicola Silvestris Behzad Baradaran |
spellingShingle |
Zahra Asadzadeh Elham Safarzadeh Sahar Safaei Ali Baradaran Ali Mohammadi Khalil Hajiasgharzadeh Afshin Derakhshani Antonella Argentiero Nicola Silvestris Behzad Baradaran Current Approaches for Combination Therapy of Cancer: The Role of Immunogenic Cell Death Cancers immunogenic cell death DAMPs combination therapy |
author_facet |
Zahra Asadzadeh Elham Safarzadeh Sahar Safaei Ali Baradaran Ali Mohammadi Khalil Hajiasgharzadeh Afshin Derakhshani Antonella Argentiero Nicola Silvestris Behzad Baradaran |
author_sort |
Zahra Asadzadeh |
title |
Current Approaches for Combination Therapy of Cancer: The Role of Immunogenic Cell Death |
title_short |
Current Approaches for Combination Therapy of Cancer: The Role of Immunogenic Cell Death |
title_full |
Current Approaches for Combination Therapy of Cancer: The Role of Immunogenic Cell Death |
title_fullStr |
Current Approaches for Combination Therapy of Cancer: The Role of Immunogenic Cell Death |
title_full_unstemmed |
Current Approaches for Combination Therapy of Cancer: The Role of Immunogenic Cell Death |
title_sort |
current approaches for combination therapy of cancer: the role of immunogenic cell death |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2020-04-01 |
description |
Cell death resistance is a key feature of tumor cells. One of the main anticancer therapies is increasing the susceptibility of cells to death. Cancer cells have developed a capability of tumor immune escape. Hence, restoring the immunogenicity of cancer cells can be suggested as an effective approach against cancer. Accumulating evidence proposes that several anticancer agents provoke the release of danger-associated molecular patterns (DAMPs) that are determinants of immunogenicity and stimulate immunogenic cell death (ICD). It has been suggested that ICD inducers are two different types according to their various activities. Here, we review the well-characterized DAMPs and focus on the different types of ICD inducers and recent combination therapies that can augment the immunogenicity of cancer cells. |
topic |
immunogenic cell death DAMPs combination therapy |
url |
https://www.mdpi.com/2072-6694/12/4/1047 |
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