The Effect of Atypical Nucleic Acids Structures in DNA Double Strand Break Repair: A Tale of R-loops and G-Quadruplexes

The Effect of Atypical Nucleic Acids Structures in DNA Double Strand Break Repair: A Tale of R-loops and G-Quadruplexes

The fine tuning of the DNA double strand break repair pathway choice relies on different regulatory layers that respond to environmental and local cues. Among them, the presence of non-canonical nucleic acids structures seems to create challenges for the repair of nearby DNA double strand breaks. In...

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Bibliographic Details
Main Authors: Rosa Camarillo, Sonia Jimeno, Pablo Huertas
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Genetics
Subjects:
R-loops
DNA double strand break repair
homologous recombination (HR)
DNA end resection
G-quadruplex
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.742434/full
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spelling doaj-54db10d75f0f47d8878b50011974a1892021-10-08T07:39:52ZengFrontiers Media S.A.Frontiers in Genetics1664-80212021-10-011210.3389/fgene.2021.742434742434The Effect of Atypical Nucleic Acids Structures in DNA Double Strand Break Repair: A Tale of R-loops and G-QuadruplexesRosa Camarillo0Rosa Camarillo1Sonia Jimeno2Sonia Jimeno3Pablo Huertas4Pablo Huertas5Departamento de Genética, Universidad de Sevilla, Sevilla, SpainCentro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Sevilla, SpainDepartamento de Genética, Universidad de Sevilla, Sevilla, SpainCentro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Sevilla, SpainDepartamento de Genética, Universidad de Sevilla, Sevilla, SpainCentro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Sevilla, SpainThe fine tuning of the DNA double strand break repair pathway choice relies on different regulatory layers that respond to environmental and local cues. Among them, the presence of non-canonical nucleic acids structures seems to create challenges for the repair of nearby DNA double strand breaks. In this review, we focus on the recently published effects of G-quadruplexes and R-loops on DNA end resection and homologous recombination. Finally, we hypothesized a connection between those two atypical DNA structures in inhibiting the DNA end resection step of HR.https://www.frontiersin.org/articles/10.3389/fgene.2021.742434/fullR-loopsDNA double strand break repairhomologous recombination (HR)DNA end resectionG-quadruplex
collection DOAJ
language English
format Article
sources DOAJ
author Rosa Camarillo
Rosa Camarillo
Sonia Jimeno
Sonia Jimeno
Pablo Huertas
Pablo Huertas
spellingShingle Rosa Camarillo
Rosa Camarillo
Sonia Jimeno
Sonia Jimeno
Pablo Huertas
Pablo Huertas
The Effect of Atypical Nucleic Acids Structures in DNA Double Strand Break Repair: A Tale of R-loops and G-Quadruplexes
Frontiers in Genetics
R-loops
DNA double strand break repair
homologous recombination (HR)
DNA end resection
G-quadruplex
author_facet Rosa Camarillo
Rosa Camarillo
Sonia Jimeno
Sonia Jimeno
Pablo Huertas
Pablo Huertas
author_sort Rosa Camarillo
title The Effect of Atypical Nucleic Acids Structures in DNA Double Strand Break Repair: A Tale of R-loops and G-Quadruplexes
title_short The Effect of Atypical Nucleic Acids Structures in DNA Double Strand Break Repair: A Tale of R-loops and G-Quadruplexes
title_full The Effect of Atypical Nucleic Acids Structures in DNA Double Strand Break Repair: A Tale of R-loops and G-Quadruplexes
title_fullStr The Effect of Atypical Nucleic Acids Structures in DNA Double Strand Break Repair: A Tale of R-loops and G-Quadruplexes
title_full_unstemmed The Effect of Atypical Nucleic Acids Structures in DNA Double Strand Break Repair: A Tale of R-loops and G-Quadruplexes
title_sort effect of atypical nucleic acids structures in dna double strand break repair: a tale of r-loops and g-quadruplexes
publisher Frontiers Media S.A.
series Frontiers in Genetics
issn 1664-8021
publishDate 2021-10-01
description The fine tuning of the DNA double strand break repair pathway choice relies on different regulatory layers that respond to environmental and local cues. Among them, the presence of non-canonical nucleic acids structures seems to create challenges for the repair of nearby DNA double strand breaks. In this review, we focus on the recently published effects of G-quadruplexes and R-loops on DNA end resection and homologous recombination. Finally, we hypothesized a connection between those two atypical DNA structures in inhibiting the DNA end resection step of HR.
topic R-loops
DNA double strand break repair
homologous recombination (HR)
DNA end resection
G-quadruplex
url https://www.frontiersin.org/articles/10.3389/fgene.2021.742434/full
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