The deleterious effect of cholesterol and protection by quercetin on mitochondrial bioenergetics of pancreatic β-cells, glycemic control and inflammation: In vitro and in vivo studies

The deleterious effect of cholesterol and protection by quercetin on mitochondrial bioenergetics of pancreatic β-cells, glycemic control and inflammation: In vitro and in vivo studies

Studying rats fed high cholesterol diet and a pancreatic β-cell line (Min6), we aimed to determine the mechanisms by which quercetin protects against cholesterol-induced pancreatic β-cell dysfunction and impairments in glycemic control. Quercetin prevented the increase in total plasma cholesterol, b...

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Bibliographic Details
Main Authors: Catalina Carrasco-Pozo, Kah Ni Tan, Marjorie Reyes-Farias, Nicole De La Jara, Shyuan Thieu Ngo, Diego Fernando Garcia-Diaz, Paola Llanos, Maria Jose Cires, Karin Borges
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Redox Biology
Subjects:
Cholesterol
Glycemic control
Mitochondrial dysfunction
Quercetin
Sirtuin-1
NFκB
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231716301215

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http://www.sciencedirect.com/science/article/pii/S2213231716301215

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