Activité anti-androgénique de Leptadenia hastata (Pers.) Decne : effet compétitif des extraits aqueux de la plante et du propionate de testostérone sur des rats impubères castrés
Anti-androgenic activity of Leptadenia hastata (Pers.) Decne: competitive effect of the aqueous extracts of the plant and the testosterone propionate on castrated immature rats. The anti-androgenic activity and the evaluation of competitiveness between the extracts of Leptadenia hastata and the test...
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Presses Agronomiques de Gembloux
2011-01-01
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Online Access: | http://www.pressesagro.be/base/text/v15n2/223.pdf |
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doaj-54f65dc7091d45b89f33508b546c53062020-11-24T22:42:33ZengPresses Agronomiques de GemblouxBiotechnologie, Agronomie, Société et Environnement1370-62331780-45072011-01-01152223229Activité anti-androgénique de Leptadenia hastata (Pers.) Decne : effet compétitif des extraits aqueux de la plante et du propionate de testostérone sur des rats impubères castrésBayala, B.Rubio-Pellicer, MT.Zongo, M.Malpaux, B.Sawadogo, L.Anti-androgenic activity of Leptadenia hastata (Pers.) Decne: competitive effect of the aqueous extracts of the plant and the testosterone propionate on castrated immature rats. The anti-androgenic activity and the evaluation of competitiveness between the extracts of Leptadenia hastata and the testosterone propionate (TP) were studied on Wistar immature castrated rats. The first group received only 0.04; 0.4; 4; 40; 400 and 1,000 µg.kg-1 of TP and the second group received simultaneously these different doses of TP and 200 mg.kg-1 of L. hastata. The various treatments showed a significant increase (p < 0.05) of the weight of androgeno-dependent organs and the level of plasmatic testosterone. At low dosis of TP, the dosis of 200 mg.kg-1 of L. hastata inhibited TP effects, whereas at high doses of TP L. hastata extracts potentiated TP effects. In conclusion, the anti-androgenic effect of the extract of L. hastata is expressed when the TP amounts are weak.http://www.pressesagro.be/base/text/v15n2/223.pdfAnti-androgenic activityHershberger testLeptadenia hastatatestosterone propionaterats |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bayala, B. Rubio-Pellicer, MT. Zongo, M. Malpaux, B. Sawadogo, L. |
spellingShingle |
Bayala, B. Rubio-Pellicer, MT. Zongo, M. Malpaux, B. Sawadogo, L. Activité anti-androgénique de Leptadenia hastata (Pers.) Decne : effet compétitif des extraits aqueux de la plante et du propionate de testostérone sur des rats impubères castrés Biotechnologie, Agronomie, Société et Environnement Anti-androgenic activity Hershberger test Leptadenia hastata testosterone propionate rats |
author_facet |
Bayala, B. Rubio-Pellicer, MT. Zongo, M. Malpaux, B. Sawadogo, L. |
author_sort |
Bayala, B. |
title |
Activité anti-androgénique de Leptadenia hastata (Pers.) Decne : effet compétitif des extraits aqueux de la plante et du propionate de testostérone sur des rats impubères castrés |
title_short |
Activité anti-androgénique de Leptadenia hastata (Pers.) Decne : effet compétitif des extraits aqueux de la plante et du propionate de testostérone sur des rats impubères castrés |
title_full |
Activité anti-androgénique de Leptadenia hastata (Pers.) Decne : effet compétitif des extraits aqueux de la plante et du propionate de testostérone sur des rats impubères castrés |
title_fullStr |
Activité anti-androgénique de Leptadenia hastata (Pers.) Decne : effet compétitif des extraits aqueux de la plante et du propionate de testostérone sur des rats impubères castrés |
title_full_unstemmed |
Activité anti-androgénique de Leptadenia hastata (Pers.) Decne : effet compétitif des extraits aqueux de la plante et du propionate de testostérone sur des rats impubères castrés |
title_sort |
activité anti-androgénique de leptadenia hastata (pers.) decne : effet compétitif des extraits aqueux de la plante et du propionate de testostérone sur des rats impubères castrés |
publisher |
Presses Agronomiques de Gembloux |
series |
Biotechnologie, Agronomie, Société et Environnement |
issn |
1370-6233 1780-4507 |
publishDate |
2011-01-01 |
description |
Anti-androgenic activity of Leptadenia hastata (Pers.) Decne: competitive effect of the aqueous extracts of the plant and the testosterone propionate on castrated immature rats. The anti-androgenic activity and the evaluation of competitiveness between the extracts of Leptadenia hastata and the testosterone propionate (TP) were studied on Wistar immature castrated rats. The first group received only 0.04; 0.4; 4; 40; 400 and 1,000 µg.kg-1 of TP and the second group received simultaneously these different doses of TP and 200 mg.kg-1 of L. hastata. The various treatments showed a significant increase (p < 0.05) of the weight of androgeno-dependent organs and the level of plasmatic testosterone. At low dosis of TP, the dosis of 200 mg.kg-1 of L. hastata inhibited TP effects, whereas at high doses of TP L. hastata extracts potentiated TP effects. In conclusion, the anti-androgenic effect of the extract of L. hastata is expressed when the TP amounts are weak. |
topic |
Anti-androgenic activity Hershberger test Leptadenia hastata testosterone propionate rats |
url |
http://www.pressesagro.be/base/text/v15n2/223.pdf |
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