Nogo-A-deficient transgenic rats show deficits in higher cognitive functions, decreased anxiety and altered circadian activity patterns

• Main Authors: Tomas ePetrasek, Iva eProkopova, Martin eSladek, Kamila eWeissova, Iveta eVojtechova, Stepan eBahnik, Anna eZemanova, Kai eSchönig, Stefan eBerger, Björn eTews, Dusan eBartsch, Martin eSchwab, Alena eSumova, Ales eStuchlik
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2014-03-01
• Series: Frontiers in Behavioral Neuroscience
• Subjects: Anhedonia; Cognition; Spatial learning; Nogo-A; passive avoidance; circadian rhythmicity
• Online Access: http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00090/full

Decreased levels of Nogo-A dependent signaling have been shown to affect behavior and cognitive functions. In Nogo-A knockout and knock-down laboratory rodents, behavioral alterations were observed, possibly corresponding with human neuropsychiatric diseases of neurodevelopmental origin, particularly schizophrenia. This study offers further insight into behavioral manifestations of Nogo-A knockdown in laboratory rats, focusing on spatial and non-spatial cognition, anxiety levels, circadian rhythmicity and activity patterns. Demonstrated is an impairment of cognitive functions and behavioral flexibility in a spatial active avoidance task, while non-spatial memory in a step-through avoidance task was spared. No signs of anhedonia, typical for schizophrenic patients, were observed in the animals. Some measures indicated lower anxiety levels in the Nogo-A deficient group. Circadian rhythmicity in locomotor activity was preserved in the Nogo-A-knockout rats and their circadian period (tau) did not differ from controls. However, daily activity patterns were slightly altered in the knockdown animals. We conclude that a reduction of Nogo-A levels induces changes in CNS development, manifested as subtle alterations in cognitive functions, emotionality and activity patterns.