Common variable immunodeficiency and isosporiasis: first report case

• Main Authors: Gisele Barbosa e Silva, Karla Pereira Fernandes, Gesmar Rodrigues Silva Segundo
• Format: Article
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT) 2012-12-01
• Series: Revista da Sociedade Brasileira de Medicina Tropical
• Subjects: Isosporiase; Imunodeficiência primária; Imunodeficiência comum variável
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000600023&lng=en&tlng=en

We report a severe case of diarrhea in a 62-year-old female HIV-negative patient from whom Giardia lamblia and Isospora belli were isolated. Because unusual and opportunistic infections should be considered as criteria for further analysis of immunological status, laboratory investigations led to a diagnosis of common variable immunodeficiency (CVID). This is the first reported case of isosporiasis in a patient with CVID and illustrates the importance of being aware of a possible link, particularly in relation to primary immunodeficiency.