Calcium-Sensing Receptor (CaSR), Its Impact on Inflammation and the Consequences on Cardiovascular Health
The calcium Sensing Receptor (CaSR) is a cell surface receptor belonging to the family of G-protein coupled receptors. CaSR is mainly expressed by parathyroid glands, kidneys, bone, skin, adipose tissue, the gut, the nervous system, and the cardiovascular system. The receptor, as its name implies is...
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doaj-5519859b1b4e4867b9d58261a446c6b22021-03-02T00:04:22ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-03-01222478247810.3390/ijms22052478Calcium-Sensing Receptor (CaSR), Its Impact on Inflammation and the Consequences on Cardiovascular HealthSai Sahana Sundararaman0Emiel P. C. van der Vorst1Interdisciplinary Centre for Clinical Research (IZKF), RWTH Aachen University, 52074 Aachen, GermanyInterdisciplinary Centre for Clinical Research (IZKF), RWTH Aachen University, 52074 Aachen, GermanyThe calcium Sensing Receptor (CaSR) is a cell surface receptor belonging to the family of G-protein coupled receptors. CaSR is mainly expressed by parathyroid glands, kidneys, bone, skin, adipose tissue, the gut, the nervous system, and the cardiovascular system. The receptor, as its name implies is involved in sensing calcium fluctuations in the extracellular matrix of cells, thereby having a major impact on the mineral homeostasis in humans. Besides calcium ions, the receptor is also activated by other di- and tri-valent cations, polypeptides, polyamines, antibiotics, calcilytics and calcimimetics, which upon binding induce intracellular signaling pathways. Recent studies have demonstrated that CaSR influences a wide variety of cells and processes that are involved in inflammation, the cardiovascular system, such as vascular calcification, atherosclerosis, myocardial infarction, hypertension, and obesity. Therefore, in this review, the current understanding of the role that CaSR plays in inflammation and its consequences on the cardiovascular system will be highlighted.https://www.mdpi.com/1422-0067/22/5/2478calcium-sensing receptorCaSRG-protein coupled receptorsinflammationcardiovascular disordersatherosclerosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sai Sahana Sundararaman Emiel P. C. van der Vorst |
spellingShingle |
Sai Sahana Sundararaman Emiel P. C. van der Vorst Calcium-Sensing Receptor (CaSR), Its Impact on Inflammation and the Consequences on Cardiovascular Health International Journal of Molecular Sciences calcium-sensing receptor CaSR G-protein coupled receptors inflammation cardiovascular disorders atherosclerosis |
author_facet |
Sai Sahana Sundararaman Emiel P. C. van der Vorst |
author_sort |
Sai Sahana Sundararaman |
title |
Calcium-Sensing Receptor (CaSR), Its Impact on Inflammation and the Consequences on Cardiovascular Health |
title_short |
Calcium-Sensing Receptor (CaSR), Its Impact on Inflammation and the Consequences on Cardiovascular Health |
title_full |
Calcium-Sensing Receptor (CaSR), Its Impact on Inflammation and the Consequences on Cardiovascular Health |
title_fullStr |
Calcium-Sensing Receptor (CaSR), Its Impact on Inflammation and the Consequences on Cardiovascular Health |
title_full_unstemmed |
Calcium-Sensing Receptor (CaSR), Its Impact on Inflammation and the Consequences on Cardiovascular Health |
title_sort |
calcium-sensing receptor (casr), its impact on inflammation and the consequences on cardiovascular health |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2021-03-01 |
description |
The calcium Sensing Receptor (CaSR) is a cell surface receptor belonging to the family of G-protein coupled receptors. CaSR is mainly expressed by parathyroid glands, kidneys, bone, skin, adipose tissue, the gut, the nervous system, and the cardiovascular system. The receptor, as its name implies is involved in sensing calcium fluctuations in the extracellular matrix of cells, thereby having a major impact on the mineral homeostasis in humans. Besides calcium ions, the receptor is also activated by other di- and tri-valent cations, polypeptides, polyamines, antibiotics, calcilytics and calcimimetics, which upon binding induce intracellular signaling pathways. Recent studies have demonstrated that CaSR influences a wide variety of cells and processes that are involved in inflammation, the cardiovascular system, such as vascular calcification, atherosclerosis, myocardial infarction, hypertension, and obesity. Therefore, in this review, the current understanding of the role that CaSR plays in inflammation and its consequences on the cardiovascular system will be highlighted. |
topic |
calcium-sensing receptor CaSR G-protein coupled receptors inflammation cardiovascular disorders atherosclerosis |
url |
https://www.mdpi.com/1422-0067/22/5/2478 |
work_keys_str_mv |
AT saisahanasundararaman calciumsensingreceptorcasritsimpactoninflammationandtheconsequencesoncardiovascularhealth AT emielpcvandervorst calciumsensingreceptorcasritsimpactoninflammationandtheconsequencesoncardiovascularhealth |
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