HCV culture system and its application in antiviral research on Chinese herb extracts in vitro

• Main Author: LI Jingtao
• Format: Article
• Language: zho
• Published: Editorial Department of Journal of Clinical Hepatology 2015-01-01
• Series: Linchuang Gandanbing Zazhi
• Subjects: hepatitis C; chronic; hepacivirus; drug; Chinese herbal; cell culture techniques; replicon; review
• Online Access: http://www.lcgdbzz.org/qk_content.asp?id=6328&ClassID=11416741

Many studies have shown that Chinese herb extracts could treat patients who suffer hepatitis C. However, the clinical efficacy is limited due to the use of traditional Chinese medicine (TCM) compounds. Because each drug contains multiple active substances, some of which may even act against each other in vivo, it is hard to clarify the mechanism of treatment. The current research on pseudotyped hepatitis C virus (HCV), replicon, and cell culture system is summarized, and the advances in antiviral research on the monomers or active components of Chinese herbs in vitro based on HCV RNA models are reviewed, thus providing new ideas for TCM treatment of hepatitis C.