The Bulbocavernosus Reflex in the Differential Diagnosis of Multiple System Atrophy with Predominant Parkinsonism and Parkinson’s Disease
Multiple system atrophy with predominant parkinsonism (MSA-P) is a degenerative disorder that presents with autonomic dysfunction, atypical parkinsonism, and ataxia. Parkinson’s disease (PD) is an age-related neurological disorder of the central nervous system. Differentiation between MSA-P and PD i...
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doaj-551f8c851ab0403aba9ad759a72638e32020-11-24T23:39:22ZengFrontiers Media S.A.Frontiers in Neurology1664-22952018-01-01810.3389/fneur.2017.00697278395The Bulbocavernosus Reflex in the Differential Diagnosis of Multiple System Atrophy with Predominant Parkinsonism and Parkinson’s DiseaseHuan-jie Huang0Huan-jie Huang1Xing-yu Zhu2Xing-yu Zhu3Xun Wang4Zhang-yang Wang5Wan-li Zhang6Bi-cheng Chen7Chun-feng Liu8Department of Neurology, Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Neurology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, ChinaDepartment of Neurology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, ChinaSchool of the First Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, ChinaDepartment of Neurology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, ChinaDepartment of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, ChinaDepartment of Neurology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, ChinaZhejiang Provincial Top Key Discipline in Surgery, Wenzhou Key Laboratory of Surgery, Department of Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, ChinaDepartment of Neurology, Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaMultiple system atrophy with predominant parkinsonism (MSA-P) is a degenerative disorder that presents with autonomic dysfunction, atypical parkinsonism, and ataxia. Parkinson’s disease (PD) is an age-related neurological disorder of the central nervous system. Differentiation between MSA-P and PD is important because treatments, complications, and prognoses differ. The bulbocavernosus reflex (BCR) tests the afferent and efferent signals of the pudendal nerve as well as the sacral cord. In this study, we investigated differences in BCR parameters between MSA-P and PD patients. Thirty-eight MSA-P patients and 32 PD patients were selected to participate in our electrophysiological investigations. The Keypoint EMG/EP system was used to induce the BCR, and latencies and amplitudes were recorded for systematic statistical analyses. Area under the curve of the receiver operating characteristic was used to assess the specificity and sensitivity of the BCR parameters. A BCR was elicited in 76.32% of MSA-P patients and 93.75% of PD patients. The BCR latencies of the MSA-P group were longer than those of the PD group (p < 0.001). In addition, the MSA-P group had a lower BCR amplitude compared to the PD and control groups (p < 0.001). We discovered the difference between MSA-P and PD through BCR latencies and amplitudes. Compared to PD patients, MSA-P patients have longer latencies and lower amplitudes. Therefore, the BCR may be used to discriminate between MSA-P and PD in some cases.http://journal.frontiersin.org/article/10.3389/fneur.2017.00697/fullmultiple system atrophyParkinson’s diseasebulbocavernosus reflexelectrophysiological testdifferential diagnosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Huan-jie Huang Huan-jie Huang Xing-yu Zhu Xing-yu Zhu Xun Wang Zhang-yang Wang Wan-li Zhang Bi-cheng Chen Chun-feng Liu |
spellingShingle |
Huan-jie Huang Huan-jie Huang Xing-yu Zhu Xing-yu Zhu Xun Wang Zhang-yang Wang Wan-li Zhang Bi-cheng Chen Chun-feng Liu The Bulbocavernosus Reflex in the Differential Diagnosis of Multiple System Atrophy with Predominant Parkinsonism and Parkinson’s Disease Frontiers in Neurology multiple system atrophy Parkinson’s disease bulbocavernosus reflex electrophysiological test differential diagnosis |
author_facet |
Huan-jie Huang Huan-jie Huang Xing-yu Zhu Xing-yu Zhu Xun Wang Zhang-yang Wang Wan-li Zhang Bi-cheng Chen Chun-feng Liu |
author_sort |
Huan-jie Huang |
title |
The Bulbocavernosus Reflex in the Differential Diagnosis of Multiple System Atrophy with Predominant Parkinsonism and Parkinson’s Disease |
title_short |
The Bulbocavernosus Reflex in the Differential Diagnosis of Multiple System Atrophy with Predominant Parkinsonism and Parkinson’s Disease |
title_full |
The Bulbocavernosus Reflex in the Differential Diagnosis of Multiple System Atrophy with Predominant Parkinsonism and Parkinson’s Disease |
title_fullStr |
The Bulbocavernosus Reflex in the Differential Diagnosis of Multiple System Atrophy with Predominant Parkinsonism and Parkinson’s Disease |
title_full_unstemmed |
The Bulbocavernosus Reflex in the Differential Diagnosis of Multiple System Atrophy with Predominant Parkinsonism and Parkinson’s Disease |
title_sort |
bulbocavernosus reflex in the differential diagnosis of multiple system atrophy with predominant parkinsonism and parkinson’s disease |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neurology |
issn |
1664-2295 |
publishDate |
2018-01-01 |
description |
Multiple system atrophy with predominant parkinsonism (MSA-P) is a degenerative disorder that presents with autonomic dysfunction, atypical parkinsonism, and ataxia. Parkinson’s disease (PD) is an age-related neurological disorder of the central nervous system. Differentiation between MSA-P and PD is important because treatments, complications, and prognoses differ. The bulbocavernosus reflex (BCR) tests the afferent and efferent signals of the pudendal nerve as well as the sacral cord. In this study, we investigated differences in BCR parameters between MSA-P and PD patients. Thirty-eight MSA-P patients and 32 PD patients were selected to participate in our electrophysiological investigations. The Keypoint EMG/EP system was used to induce the BCR, and latencies and amplitudes were recorded for systematic statistical analyses. Area under the curve of the receiver operating characteristic was used to assess the specificity and sensitivity of the BCR parameters. A BCR was elicited in 76.32% of MSA-P patients and 93.75% of PD patients. The BCR latencies of the MSA-P group were longer than those of the PD group (p < 0.001). In addition, the MSA-P group had a lower BCR amplitude compared to the PD and control groups (p < 0.001). We discovered the difference between MSA-P and PD through BCR latencies and amplitudes. Compared to PD patients, MSA-P patients have longer latencies and lower amplitudes. Therefore, the BCR may be used to discriminate between MSA-P and PD in some cases. |
topic |
multiple system atrophy Parkinson’s disease bulbocavernosus reflex electrophysiological test differential diagnosis |
url |
http://journal.frontiersin.org/article/10.3389/fneur.2017.00697/full |
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