Coxsackievirus B Type 4 Infection in β Cells Downregulates the Chaperone Prefoldin URI to Induce a MODY4-like Diabetes via Pdx1 Silencing

Coxsackievirus B Type 4 Infection in β Cells Downregulates the Chaperone Prefoldin URI to Induce a MODY4-like Diabetes via Pdx1 Silencing

Summary: Enteroviruses are suspected to contribute to insulin-producing β cell loss and hyperglycemia-induced diabetes. However, mechanisms are not fully defined. Here, we show that coxsackievirus B type 4 (CVB4) infection in human islet-engrafted mice and in rat insulinoma cells displays loss of un...

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Bibliographic Details
Main Authors: Hugo Bernard, Ana Teijeiro, Almudena Chaves-Pérez, Cristian Perna, Basanthi Satish, Anna Novials, Jennifer P. Wang, Nabil Djouder
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Cell Reports Medicine
Subjects:
enteroviruses
coxsackievirus B Type 4
diabetes
transdifferentiation
beta cells
prefoldin URI
Online Access:http://www.sciencedirect.com/science/article/pii/S2666379120301671

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