A randomized controlled trial of the effects of hydrochlorothiazide on overactive bladder and idiopathic hypercalciuria
Overactive bladder is a stressful condition which affects around 15%—20% of 5- year-old and up to 2% of young adults. One of the most common causes of overactive bladder is hypercalciuria. Our study investigated the effect of hydrochlorothiazide (HCTZ) on overactive bladder and hypercalciuria. This...
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Wolters Kluwer Medknow Publications
2017-01-01
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Series: | Saudi Journal of Kidney Diseases and Transplantation |
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doaj-553337855ba14d3ab06e9134222008152020-11-25T00:22:23ZengWolters Kluwer Medknow PublicationsSaudi Journal of Kidney Diseases and Transplantation1319-24422017-01-0128356657010.4103/1319-2442.206458A randomized controlled trial of the effects of hydrochlorothiazide on overactive bladder and idiopathic hypercalciuriaParsa YousefichaijanFatemeh DorrehMohammad RafieiMahdyieh NaziriAtefeh AzimnejadOveractive bladder is a stressful condition which affects around 15%—20% of 5- year-old and up to 2% of young adults. One of the most common causes of overactive bladder is hypercalciuria. Our study investigated the effect of hydrochlorothiazide (HCTZ) on overactive bladder and hypercalciuria. This randomized controlled trial was conducted on 88 patients with overactive bladder and idiopathic hypercalciuria. They were randomly divided into the intervention group receiving 1 mg/kg/day of HCTZ for 3 months, and the control group receiving training without any intervention. Treatment compliance and response were reviewed monthly in each patient using a 30-day bedwetting diary. In the 1st month, the mean of bedwetting was 14.47 ± 7.06 and 12.61 ± 7.57 in the intervention and control groups, respectively (P = 0.23). In the 2nd month, it was 10.04 ± 6.32 and 10.79 ± 7.83 in the intervention and control groups, respectively (P = 0.62); and in the 3rd month, it was 6.49 ± 7.13 and 7.64 ± 7.95 in the intervention and control groups, respectively (P = 0.59). There was no significant difference between the two groups. Thus, use of HCTZ was not found to be better than urine retention control training. Therefore, one may conclude that treating hypercalciuria with HCTZ had no demonstrable effect on overactive bladder.http://www.sjkdt.org/article.asp?issn=1319-2442;year=2017;volume=28;issue=3;spage=566;epage=570;aulast=Yousefichaijan |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Parsa Yousefichaijan Fatemeh Dorreh Mohammad Rafiei Mahdyieh Naziri Atefeh Azimnejad |
spellingShingle |
Parsa Yousefichaijan Fatemeh Dorreh Mohammad Rafiei Mahdyieh Naziri Atefeh Azimnejad A randomized controlled trial of the effects of hydrochlorothiazide on overactive bladder and idiopathic hypercalciuria Saudi Journal of Kidney Diseases and Transplantation |
author_facet |
Parsa Yousefichaijan Fatemeh Dorreh Mohammad Rafiei Mahdyieh Naziri Atefeh Azimnejad |
author_sort |
Parsa Yousefichaijan |
title |
A randomized controlled trial of the effects of hydrochlorothiazide on overactive bladder and idiopathic hypercalciuria |
title_short |
A randomized controlled trial of the effects of hydrochlorothiazide on overactive bladder and idiopathic hypercalciuria |
title_full |
A randomized controlled trial of the effects of hydrochlorothiazide on overactive bladder and idiopathic hypercalciuria |
title_fullStr |
A randomized controlled trial of the effects of hydrochlorothiazide on overactive bladder and idiopathic hypercalciuria |
title_full_unstemmed |
A randomized controlled trial of the effects of hydrochlorothiazide on overactive bladder and idiopathic hypercalciuria |
title_sort |
randomized controlled trial of the effects of hydrochlorothiazide on overactive bladder and idiopathic hypercalciuria |
publisher |
Wolters Kluwer Medknow Publications |
series |
Saudi Journal of Kidney Diseases and Transplantation |
issn |
1319-2442 |
publishDate |
2017-01-01 |
description |
Overactive bladder is a stressful condition which affects around 15%—20% of 5- year-old and up to 2% of young adults. One of the most common causes of overactive bladder is hypercalciuria. Our study investigated the effect of hydrochlorothiazide (HCTZ) on overactive bladder and hypercalciuria. This randomized controlled trial was conducted on 88 patients with overactive bladder and idiopathic hypercalciuria. They were randomly divided into the intervention group receiving 1 mg/kg/day of HCTZ for 3 months, and the control group receiving training without any intervention. Treatment compliance and response were reviewed monthly in each patient using a 30-day bedwetting diary. In the 1st month, the mean of bedwetting was 14.47 ± 7.06 and 12.61 ± 7.57 in the intervention and control groups, respectively (P = 0.23). In the 2nd month, it was 10.04 ± 6.32 and 10.79 ± 7.83 in the intervention and control groups, respectively (P = 0.62); and in the 3rd month, it was 6.49 ± 7.13 and 7.64 ± 7.95 in the intervention and control groups, respectively (P = 0.59). There was no significant difference between the two groups. Thus, use of HCTZ was not found to be better than urine retention control training. Therefore, one may conclude that treating hypercalciuria with HCTZ had no demonstrable effect on overactive bladder. |
url |
http://www.sjkdt.org/article.asp?issn=1319-2442;year=2017;volume=28;issue=3;spage=566;epage=570;aulast=Yousefichaijan |
work_keys_str_mv |
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