A Novel Thiosemicarbazide-Based Fluorescent Chemosensor for Hypochlorite in Near-Perfect Aqueous Solution and Zebrafish

A Novel Thiosemicarbazide-Based Fluorescent Chemosensor for Hypochlorite in Near-Perfect Aqueous Solution and Zebrafish

A novel thiosemicarbazide-based fluorescent sensor (<b>AFC</b>) was developed. It was successfully applied to detect hypochlorite (ClO<sup>−</sup>) with fluorescence quenching in bis-tris buffer. The limit of detection of <b>AFC</b> for ClO<sup>−</sup>...

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Main Authors: Minji Lee, Donghwan Choe, Soyoung Park, Hyeongjin Kim, Soomin Jeong, Ki-Tae Kim, Cheal Kim
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Chemosensors
Subjects:
thiosemicarbazide
hypochlorite
fluorescent chemosensor
acridine
Online Access:https://www.mdpi.com/2227-9040/9/4/65
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spelling doaj-5543b80838cc4fa9963662e24e10c2a12021-03-28T23:01:44ZengMDPI AGChemosensors2227-90402021-03-019656510.3390/chemosensors9040065A Novel Thiosemicarbazide-Based Fluorescent Chemosensor for Hypochlorite in Near-Perfect Aqueous Solution and ZebrafishMinji Lee0Donghwan Choe1Soyoung Park2Hyeongjin Kim3Soomin Jeong4Ki-Tae Kim5Cheal Kim6Department of Fine Chemistry, Seoul National University of Science and Technology, Seoul 137-743, KoreaDepartment of Fine Chemistry, Seoul National University of Science and Technology, Seoul 137-743, KoreaDepartment of Fine Chemistry, Seoul National University of Science and Technology, Seoul 137-743, KoreaDepartment of Fine Chemistry, Seoul National University of Science and Technology, Seoul 137-743, KoreaDepartment of Environmental Engineering, Seoul National University of Science and Technology, Seoul 01187, KoreaDepartment of Environmental Engineering, Seoul National University of Science and Technology, Seoul 01187, KoreaDepartment of Fine Chemistry, Seoul National University of Science and Technology, Seoul 137-743, KoreaA novel thiosemicarbazide-based fluorescent sensor (<b>AFC</b>) was developed. It was successfully applied to detect hypochlorite (ClO<sup>−</sup>) with fluorescence quenching in bis-tris buffer. The limit of detection of <b>AFC</b> for ClO<sup>−</sup> was analyzed to be 58.7 μM. Importantly, <b>AFC</b> could be employed as an efficient and practical fluorescent sensor for ClO<sup>−</sup> in water sample and zebrafish. Moreover, <b>AFC</b> showed a marked selectivity to ClO<sup>−</sup> over varied competitive analytes with reactive oxygen species. The detection process of <b>AFC</b> to ClO<sup>−</sup> was illustrated by UV–visible and fluorescent spectroscopy and electrospray ionization–mass spectrometry (ESI–MS).https://www.mdpi.com/2227-9040/9/4/65thiosemicarbazidehypochloritefluorescent chemosensoracridine
collection DOAJ
language English
format Article
sources DOAJ
author Minji Lee
Donghwan Choe
Soyoung Park
Hyeongjin Kim
Soomin Jeong
Ki-Tae Kim
Cheal Kim
spellingShingle Minji Lee
Donghwan Choe
Soyoung Park
Hyeongjin Kim
Soomin Jeong
Ki-Tae Kim
Cheal Kim
A Novel Thiosemicarbazide-Based Fluorescent Chemosensor for Hypochlorite in Near-Perfect Aqueous Solution and Zebrafish
Chemosensors
thiosemicarbazide
hypochlorite
fluorescent chemosensor
acridine
author_facet Minji Lee
Donghwan Choe
Soyoung Park
Hyeongjin Kim
Soomin Jeong
Ki-Tae Kim
Cheal Kim
author_sort Minji Lee
title A Novel Thiosemicarbazide-Based Fluorescent Chemosensor for Hypochlorite in Near-Perfect Aqueous Solution and Zebrafish
title_short A Novel Thiosemicarbazide-Based Fluorescent Chemosensor for Hypochlorite in Near-Perfect Aqueous Solution and Zebrafish
title_full A Novel Thiosemicarbazide-Based Fluorescent Chemosensor for Hypochlorite in Near-Perfect Aqueous Solution and Zebrafish
title_fullStr A Novel Thiosemicarbazide-Based Fluorescent Chemosensor for Hypochlorite in Near-Perfect Aqueous Solution and Zebrafish
title_full_unstemmed A Novel Thiosemicarbazide-Based Fluorescent Chemosensor for Hypochlorite in Near-Perfect Aqueous Solution and Zebrafish
title_sort novel thiosemicarbazide-based fluorescent chemosensor for hypochlorite in near-perfect aqueous solution and zebrafish
publisher MDPI AG
series Chemosensors
issn 2227-9040
publishDate 2021-03-01
description A novel thiosemicarbazide-based fluorescent sensor (<b>AFC</b>) was developed. It was successfully applied to detect hypochlorite (ClO<sup>−</sup>) with fluorescence quenching in bis-tris buffer. The limit of detection of <b>AFC</b> for ClO<sup>−</sup> was analyzed to be 58.7 μM. Importantly, <b>AFC</b> could be employed as an efficient and practical fluorescent sensor for ClO<sup>−</sup> in water sample and zebrafish. Moreover, <b>AFC</b> showed a marked selectivity to ClO<sup>−</sup> over varied competitive analytes with reactive oxygen species. The detection process of <b>AFC</b> to ClO<sup>−</sup> was illustrated by UV–visible and fluorescent spectroscopy and electrospray ionization–mass spectrometry (ESI–MS).
topic thiosemicarbazide
hypochlorite
fluorescent chemosensor
acridine
url https://www.mdpi.com/2227-9040/9/4/65
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