Green One-pot Synthesis of Novel Polysubstituted Pyrazole Derivatives as Potential Antimicrobial Agents
Various biological properties of natural and synthetic pyrazole derivatives such as anti-inflammatory, antimicrobial, neuroprotective, anticonvulsant, antidepressant and anticancer activities encouraged us to propose a new, fast, green and eco-friendly procedure for the preparation of some novel 5-a...
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doaj-5568a3d7ea6543e8819fdb69d2eca7b82020-11-25T02:00:18ZengSlovenian Chemical SocietyActa Chimica Slovenica1318-02071580-31552017-12-0164491191810.17344/acsi.2017.3609518Green One-pot Synthesis of Novel Polysubstituted Pyrazole Derivatives as Potential Antimicrobial AgentsHamid Beyzaei0Zahra Motraghi1Reza Aryan2Mohammad Mehdi Zahedi3Alireza Samzadeh-Kermani4University of ZabolUniversity of ZabolUniversity of ZabolUniversity of SaskatchewanUniversity of ZabolVarious biological properties of natural and synthetic pyrazole derivatives such as anti-inflammatory, antimicrobial, neuroprotective, anticonvulsant, antidepressant and anticancer activities encouraged us to propose a new, fast, green and eco-friendly procedure for the preparation of some novel 5-amino-3-(aryl substituted)-1-(2,4-dinitrophenyl)-1H-pyrazole-4-carbonitriles. They were efficiently synthesized via one-pot two-step process reaction of malononitrile, 2,4-dinitrophenylhydrazine and different benzaldehydes in deep eutectic solvent (DES) glycerol/potassium carbonate. The products yield and reaction times were considerably improved in the presence of applied DES. Antibacterial effects of all newly synthesized pyrazoles in comparison with several common antibiotics were evaluated against a variety of Gram-positive and Gram-negative pathogenic bacteria. In addition to, their inhibitory activities on three fungi were compared to some current antifungal agents. The moderate to good antimicrobial potentials particularly against fungi were observed in the major heterocyclic compounds according to the IZD, MIC, MBC and MFC results.https://journals.matheo.si/index.php/ACSi/article/view/3609Green synthesisDeep eutectic solventGlycerol/potassium carbonatePolysubstituted pyrazolesAntibacterial and antifungal activities |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hamid Beyzaei Zahra Motraghi Reza Aryan Mohammad Mehdi Zahedi Alireza Samzadeh-Kermani |
spellingShingle |
Hamid Beyzaei Zahra Motraghi Reza Aryan Mohammad Mehdi Zahedi Alireza Samzadeh-Kermani Green One-pot Synthesis of Novel Polysubstituted Pyrazole Derivatives as Potential Antimicrobial Agents Acta Chimica Slovenica Green synthesis Deep eutectic solvent Glycerol/potassium carbonate Polysubstituted pyrazoles Antibacterial and antifungal activities |
author_facet |
Hamid Beyzaei Zahra Motraghi Reza Aryan Mohammad Mehdi Zahedi Alireza Samzadeh-Kermani |
author_sort |
Hamid Beyzaei |
title |
Green One-pot Synthesis of Novel Polysubstituted Pyrazole Derivatives as Potential Antimicrobial Agents |
title_short |
Green One-pot Synthesis of Novel Polysubstituted Pyrazole Derivatives as Potential Antimicrobial Agents |
title_full |
Green One-pot Synthesis of Novel Polysubstituted Pyrazole Derivatives as Potential Antimicrobial Agents |
title_fullStr |
Green One-pot Synthesis of Novel Polysubstituted Pyrazole Derivatives as Potential Antimicrobial Agents |
title_full_unstemmed |
Green One-pot Synthesis of Novel Polysubstituted Pyrazole Derivatives as Potential Antimicrobial Agents |
title_sort |
green one-pot synthesis of novel polysubstituted pyrazole derivatives as potential antimicrobial agents |
publisher |
Slovenian Chemical Society |
series |
Acta Chimica Slovenica |
issn |
1318-0207 1580-3155 |
publishDate |
2017-12-01 |
description |
Various biological properties of natural and synthetic pyrazole derivatives such as anti-inflammatory, antimicrobial, neuroprotective, anticonvulsant, antidepressant and anticancer activities encouraged us to propose a new, fast, green and eco-friendly procedure for the preparation of some novel 5-amino-3-(aryl substituted)-1-(2,4-dinitrophenyl)-1H-pyrazole-4-carbonitriles. They were efficiently synthesized via one-pot two-step process reaction of malononitrile, 2,4-dinitrophenylhydrazine and different benzaldehydes in deep eutectic solvent (DES) glycerol/potassium carbonate. The products yield and reaction times were considerably improved in the presence of applied DES. Antibacterial effects of all newly synthesized pyrazoles in comparison with several common antibiotics were evaluated against a variety of Gram-positive and Gram-negative pathogenic bacteria. In addition to, their inhibitory activities on three fungi were compared to some current antifungal agents. The moderate to good antimicrobial potentials particularly against fungi were observed in the major heterocyclic compounds according to the IZD, MIC, MBC and MFC results. |
topic |
Green synthesis Deep eutectic solvent Glycerol/potassium carbonate Polysubstituted pyrazoles Antibacterial and antifungal activities |
url |
https://journals.matheo.si/index.php/ACSi/article/view/3609 |
work_keys_str_mv |
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1724961501380345856 |