Spinogenesis and pruning in the anterior ventral inferotemporal cortex of the macaque monkey: an intracellular injection study of layer III pyramidal cells
Cortical pyramidal cells grow and mature at different rates in visual, auditory and prefrontal cortex of the macaque monkey. In particular, differences across the areas have been reported in both the timing and magnitude of growth, branching, spinogenesis and pruning in the basal dendritic trees of...
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doaj-557214d895e04ac996d9cef8f35616ea2020-11-24T22:41:44ZengFrontiers Media S.A.Frontiers in Neuroanatomy1662-51292011-07-01510.3389/fnana.2011.0004212169Spinogenesis and pruning in the anterior ventral inferotemporal cortex of the macaque monkey: an intracellular injection study of layer III pyramidal cellsGuy N. Elston0Tomofumi eOga1Tsuguhisa eOkamoto2Ichiro eFujita3Centre for Cognitive NeuroscienceOsaka UniversityOsaka UniversityOsaka UniversityCortical pyramidal cells grow and mature at different rates in visual, auditory and prefrontal cortex of the macaque monkey. In particular, differences across the areas have been reported in both the timing and magnitude of growth, branching, spinogenesis and pruning in the basal dendritic trees of cells in layer III. Presently available data suggest that these different growth profiles reflect the type of functions performed by these cells in the adult brain. However, to date, studies have focussed on only a relatively few cortical areas. In the present investigation we quantified the growth of the dendritic trees of layer III pyramidal cells in the anterior ventral portion of cytoarchitectonic area TE (TEav) to better comprehend developmental trends in the cerebral cortex. We quantified the growth and branching of the dendrities, and spinogenesis and pruning of spines, from post-natal day 2 (PND2) to four and a half years of age. We found that the dendritic trees increase in size from PND2 to 7 months of age and thereafter become smaller. The dendritic trees became increasingly more branched from PND2 into adulthood. There was a 2-fold increase in the number of spines in the basal dendritic trees of pyramidal cells from PND2 to 3½ months of age and then a 10% net decrease in spine number into adulthood. Thus, the growth profile of layer III pyramidal cells in the anterior ventral portion of the inferotemporal cortex differs to that in other cortical areas associated with visual processing.http://journal.frontiersin.org/Journal/10.3389/fnana.2011.00042/fullSpinedevelopmentplasticityDendriteCortexmaturation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Guy N. Elston Tomofumi eOga Tsuguhisa eOkamoto Ichiro eFujita |
spellingShingle |
Guy N. Elston Tomofumi eOga Tsuguhisa eOkamoto Ichiro eFujita Spinogenesis and pruning in the anterior ventral inferotemporal cortex of the macaque monkey: an intracellular injection study of layer III pyramidal cells Frontiers in Neuroanatomy Spine development plasticity Dendrite Cortex maturation |
author_facet |
Guy N. Elston Tomofumi eOga Tsuguhisa eOkamoto Ichiro eFujita |
author_sort |
Guy N. Elston |
title |
Spinogenesis and pruning in the anterior ventral inferotemporal cortex of the macaque monkey: an intracellular injection study of layer III pyramidal cells |
title_short |
Spinogenesis and pruning in the anterior ventral inferotemporal cortex of the macaque monkey: an intracellular injection study of layer III pyramidal cells |
title_full |
Spinogenesis and pruning in the anterior ventral inferotemporal cortex of the macaque monkey: an intracellular injection study of layer III pyramidal cells |
title_fullStr |
Spinogenesis and pruning in the anterior ventral inferotemporal cortex of the macaque monkey: an intracellular injection study of layer III pyramidal cells |
title_full_unstemmed |
Spinogenesis and pruning in the anterior ventral inferotemporal cortex of the macaque monkey: an intracellular injection study of layer III pyramidal cells |
title_sort |
spinogenesis and pruning in the anterior ventral inferotemporal cortex of the macaque monkey: an intracellular injection study of layer iii pyramidal cells |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neuroanatomy |
issn |
1662-5129 |
publishDate |
2011-07-01 |
description |
Cortical pyramidal cells grow and mature at different rates in visual, auditory and prefrontal cortex of the macaque monkey. In particular, differences across the areas have been reported in both the timing and magnitude of growth, branching, spinogenesis and pruning in the basal dendritic trees of cells in layer III. Presently available data suggest that these different growth profiles reflect the type of functions performed by these cells in the adult brain. However, to date, studies have focussed on only a relatively few cortical areas. In the present investigation we quantified the growth of the dendritic trees of layer III pyramidal cells in the anterior ventral portion of cytoarchitectonic area TE (TEav) to better comprehend developmental trends in the cerebral cortex. We quantified the growth and branching of the dendrities, and spinogenesis and pruning of spines, from post-natal day 2 (PND2) to four and a half years of age. We found that the dendritic trees increase in size from PND2 to 7 months of age and thereafter become smaller. The dendritic trees became increasingly more branched from PND2 into adulthood. There was a 2-fold increase in the number of spines in the basal dendritic trees of pyramidal cells from PND2 to 3½ months of age and then a 10% net decrease in spine number into adulthood. Thus, the growth profile of layer III pyramidal cells in the anterior ventral portion of the inferotemporal cortex differs to that in other cortical areas associated with visual processing. |
topic |
Spine development plasticity Dendrite Cortex maturation |
url |
http://journal.frontiersin.org/Journal/10.3389/fnana.2011.00042/full |
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