The role of myelin damage in Alzheimer’s disease pathology
Although Alois Alzheimer described myelin disruption in Alzheimer’s disease (AD) as early as in 1911, his observation has escaped the attention of researchers since that time. Alzheimer’s disease has been mainly considered as a grey matter disorder; nevertheless, recent evidence suggests that myelin...
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Termedia Publishing House
2018-08-01
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doaj-557cf6dbbf62411f928f61affc0d7e962020-11-25T03:02:39ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512018-08-0116234534110.5114/aoms.2018.7686333217The role of myelin damage in Alzheimer’s disease pathologyEwa PapućKonrad RejdakAlthough Alois Alzheimer described myelin disruption in Alzheimer’s disease (AD) as early as in 1911, his observation has escaped the attention of researchers since that time. Alzheimer’s disease has been mainly considered as a grey matter disorder; nevertheless, recent evidence suggests that myelin impairment may play an important role in AD pathology. Classical neuropathological changes in AD, e.g. the accumulation of aggregated Aβ 42 and the presence of neurofibrillary tangles, are responsible for neuronal loss, but they may also induce death of oligodendrocytes and myelin damage. There is also evidence that myelin pathology may even precede Aβ and tau pathologies in AD. The state of the art does not allow us to determine whether myelin damage is a primary or a secondary injury in AD subjects. The article presents an overview of current knowledge on the role of myelin in AD pathology and its interactions with Aβ and tau pathologies.https://www.termedia.pl/The-role-of-myelin-damage-in-Alzheimer-s-disease-pathology,19,33217,1,1.htmlalzheimer’s disease myelin impairment white matter damage oligodendroglia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ewa Papuć Konrad Rejdak |
spellingShingle |
Ewa Papuć Konrad Rejdak The role of myelin damage in Alzheimer’s disease pathology Archives of Medical Science alzheimer’s disease myelin impairment white matter damage oligodendroglia |
author_facet |
Ewa Papuć Konrad Rejdak |
author_sort |
Ewa Papuć |
title |
The role of myelin damage in Alzheimer’s disease pathology |
title_short |
The role of myelin damage in Alzheimer’s disease pathology |
title_full |
The role of myelin damage in Alzheimer’s disease pathology |
title_fullStr |
The role of myelin damage in Alzheimer’s disease pathology |
title_full_unstemmed |
The role of myelin damage in Alzheimer’s disease pathology |
title_sort |
role of myelin damage in alzheimer’s disease pathology |
publisher |
Termedia Publishing House |
series |
Archives of Medical Science |
issn |
1734-1922 1896-9151 |
publishDate |
2018-08-01 |
description |
Although Alois Alzheimer described myelin disruption in Alzheimer’s disease (AD) as early as in 1911, his observation has escaped the attention of researchers since that time. Alzheimer’s disease has been mainly considered as a grey matter disorder; nevertheless, recent evidence suggests that myelin impairment may play an important role in AD pathology. Classical neuropathological changes in AD, e.g. the accumulation of aggregated Aβ 42 and the presence of neurofibrillary tangles, are responsible for neuronal loss, but they may also induce death of oligodendrocytes and myelin damage. There is also evidence that myelin pathology may even precede Aβ and tau pathologies in AD. The state of the art does not allow us to determine whether myelin damage is a primary or a secondary injury in AD subjects. The article presents an overview of current knowledge on the role of myelin in AD pathology and its interactions with Aβ and tau pathologies. |
topic |
alzheimer’s disease myelin impairment white matter damage oligodendroglia |
url |
https://www.termedia.pl/The-role-of-myelin-damage-in-Alzheimer-s-disease-pathology,19,33217,1,1.html |
work_keys_str_mv |
AT ewapapuc theroleofmyelindamageinalzheimersdiseasepathology AT konradrejdak theroleofmyelindamageinalzheimersdiseasepathology AT ewapapuc roleofmyelindamageinalzheimersdiseasepathology AT konradrejdak roleofmyelindamageinalzheimersdiseasepathology |
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1724689069246513152 |