Serum cystatin C in estimating glomerular filtration rate
Using serum cystatin C in estimating glomerular filtration rate (GFR) has in recent times been recommended. A number of simple formulas for calculating GFR have been derived specifically from serum cystatin C concentrations. The purpose of this study was to assess the significance of cystatin C and...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Society of Medical Biochemists of Serbia, Belgrade
2008-01-01
|
Series: | Journal of Medical Biochemistry |
Subjects: | |
Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2008/1452-82580801046C.pdf |
id |
doaj-557d654e83d84492b44f04ed1251aa70 |
---|---|
record_format |
Article |
spelling |
doaj-557d654e83d84492b44f04ed1251aa702020-11-25T02:38:07ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662008-01-0127146511452-82580801046CSerum cystatin C in estimating glomerular filtration rateČabarkapa Velibor0https://orcid.org/0000-0001-7166-3379Stošić Zoran1Đerić Mirjana2Vučurević-Ristić Ljiljana3Žeravica Radmila4Ilinčić Branislava5Institute of Laboratory Medicine, Clinical Centre of Vojvodina, Novi SadInstitute of Laboratory Medicine, Clinical Centre of Vojvodina, Novi SadInstitute of Laboratory Medicine, Clinical Centre of Vojvodina, Novi SadInstitute of Laboratory Medicine, Clinical Centre of Vojvodina, Novi SadInstitute of Laboratory Medicine, Clinical Centre of Vojvodina, Novi SadInstitute of Laboratory Medicine, Clinical Centre of Vojvodina, Novi SadUsing serum cystatin C in estimating glomerular filtration rate (GFR) has in recent times been recommended. A number of simple formulas for calculating GFR have been derived specifically from serum cystatin C concentrations. The purpose of this study was to assess the significance of cystatin C and of the two most frequently applied of these formulas in estimating glomerular filtration rate compared to serum creatinine and its derived formulas for estimating glomerular filtration rate from creatinine concentrations. The study included 74 patients: 59 were in various stages of chronic renal insufficiency (divided into two subgroups: I with GFR < 60 mL/min/1.73m2 and II with GFR<60 mL/min/1.73m2) and 15 on hemodialysis. A control group of 30 healthy participants was also included in the study. Serum values of cystatin C ranged from: 0.86 ± 0.16 mg/L in subgroup I, and 1.77 ± 0.79 mg/L in subgroup II, to 6.9 ± 1.83 mg/L in patients on hemodialysis. The correlation between the two formulas derived from cystatin C and the clearance of creatinine, as well as the Cockcroft and Gault's formula, was significant, while one of the formulas derived from cystatin C did not show a significant correlation with MDRD. It was concluded that serum cystatin C is a significant marker in estimating glomerular filtration rate, especially in the advanced stages of chronic renal insufficiency.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2008/1452-82580801046C.pdfcystatin ccockcroft-gault formulamdrd(modification of diet in renal disease)creatinineglomerularfiltration rate |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Čabarkapa Velibor Stošić Zoran Đerić Mirjana Vučurević-Ristić Ljiljana Žeravica Radmila Ilinčić Branislava |
spellingShingle |
Čabarkapa Velibor Stošić Zoran Đerić Mirjana Vučurević-Ristić Ljiljana Žeravica Radmila Ilinčić Branislava Serum cystatin C in estimating glomerular filtration rate Journal of Medical Biochemistry cystatin c cockcroft-gault formula mdrd(modification of diet in renal disease) creatinine glomerularfiltration rate |
author_facet |
Čabarkapa Velibor Stošić Zoran Đerić Mirjana Vučurević-Ristić Ljiljana Žeravica Radmila Ilinčić Branislava |
author_sort |
Čabarkapa Velibor |
title |
Serum cystatin C in estimating glomerular filtration rate |
title_short |
Serum cystatin C in estimating glomerular filtration rate |
title_full |
Serum cystatin C in estimating glomerular filtration rate |
title_fullStr |
Serum cystatin C in estimating glomerular filtration rate |
title_full_unstemmed |
Serum cystatin C in estimating glomerular filtration rate |
title_sort |
serum cystatin c in estimating glomerular filtration rate |
publisher |
Society of Medical Biochemists of Serbia, Belgrade |
series |
Journal of Medical Biochemistry |
issn |
1452-8258 1452-8266 |
publishDate |
2008-01-01 |
description |
Using serum cystatin C in estimating glomerular filtration rate (GFR) has in recent times been recommended. A number of simple formulas for calculating GFR have been derived specifically from serum cystatin C concentrations. The purpose of this study was to assess the significance of cystatin C and of the two most frequently applied of these formulas in estimating glomerular filtration rate compared to serum creatinine and its derived formulas for estimating glomerular filtration rate from creatinine concentrations. The study included 74 patients: 59 were in various stages of chronic renal insufficiency (divided into two subgroups: I with GFR < 60 mL/min/1.73m2 and II with GFR<60 mL/min/1.73m2) and 15 on hemodialysis. A control group of 30 healthy participants was also included in the study. Serum values of cystatin C ranged from: 0.86 ± 0.16 mg/L in subgroup I, and 1.77 ± 0.79 mg/L in subgroup II, to 6.9 ± 1.83 mg/L in patients on hemodialysis. The correlation between the two formulas derived from cystatin C and the clearance of creatinine, as well as the Cockcroft and Gault's formula, was significant, while one of the formulas derived from cystatin C did not show a significant correlation with MDRD. It was concluded that serum cystatin C is a significant marker in estimating glomerular filtration rate, especially in the advanced stages of chronic renal insufficiency. |
topic |
cystatin c cockcroft-gault formula mdrd(modification of diet in renal disease) creatinine glomerularfiltration rate |
url |
https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2008/1452-82580801046C.pdf |
work_keys_str_mv |
AT cabarkapavelibor serumcystatincinestimatingglomerularfiltrationrate AT stosiczoran serumcystatincinestimatingglomerularfiltrationrate AT đericmirjana serumcystatincinestimatingglomerularfiltrationrate AT vucurevicristicljiljana serumcystatincinestimatingglomerularfiltrationrate AT zeravicaradmila serumcystatincinestimatingglomerularfiltrationrate AT ilincicbranislava serumcystatincinestimatingglomerularfiltrationrate |
_version_ |
1724792569449152512 |