Microarray-Based Gene Expression Profiling to Elucidate Effectiveness of Fermented Codonopsis lanceolata in Mice
In this study, the effect of Codonopsis lanceolata fermented by lactic acid on controlling gene expression levels related to obesity was observed in an oligonucleotide chip microarray. Among 8170 genes, 393 genes were up regulated and 760 genes were down regulated in feeding the fermented C. lanceol...
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2014-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | http://www.mdpi.com/1422-0067/15/4/5907 |
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doaj-557ea20166bf4bed9c89a9e1deb3295a2020-11-25T02:09:17ZengMDPI AGInternational Journal of Molecular Sciences1422-00672014-04-011545907591510.3390/ijms15045907ijms15045907Microarray-Based Gene Expression Profiling to Elucidate Effectiveness of Fermented Codonopsis lanceolata in MiceWoon Yong Choi0Ji Seon Kim1Sung Jin Park2Choong Je Ma3Hyeon Yong Lee4Department of Medical Biomaterials Engineering, Kangwon National University, Chuncheon 200-701, KoreaDepartment of Medical Biomaterials Engineering, Kangwon National University, Chuncheon 200-701, KoreaDepartment of Tourism Food Service Cuisine, Hallym Polytechnic University, Gangwon 200-711, KoreaDepartment of Medical Biomaterials Engineering, Kangwon National University, Chuncheon 200-701, KoreaDepartment of Food Science and Technology, Seowon University, Cheongju, Chungbuk 361-742, KoreaIn this study, the effect of Codonopsis lanceolata fermented by lactic acid on controlling gene expression levels related to obesity was observed in an oligonucleotide chip microarray. Among 8170 genes, 393 genes were up regulated and 760 genes were down regulated in feeding the fermented C. lanceolata (FCL). Another 374 genes were up regulated and 527 genes down regulated without feeding the sample. The genes were not affected by the FCL sample. It was interesting that among those genes, Chytochrome P450, Dmbt1, LOC76487, and thyroid hormones, etc., were mostly up or down regulated. These genes are more related to lipid synthesis. We could conclude that the FCL possibly controlled the gene expression levels related to lipid synthesis, which resulted in reducing obesity. However, more detailed protein expression experiments should be carried out.http://www.mdpi.com/1422-0067/15/4/5907fermented Codonopsis lanceolatamicroarraygene expressionobesity |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Woon Yong Choi Ji Seon Kim Sung Jin Park Choong Je Ma Hyeon Yong Lee |
| spellingShingle |
Woon Yong Choi Ji Seon Kim Sung Jin Park Choong Je Ma Hyeon Yong Lee Microarray-Based Gene Expression Profiling to Elucidate Effectiveness of Fermented Codonopsis lanceolata in Mice International Journal of Molecular Sciences fermented Codonopsis lanceolata microarray gene expression obesity |
| author_facet |
Woon Yong Choi Ji Seon Kim Sung Jin Park Choong Je Ma Hyeon Yong Lee |
| author_sort |
Woon Yong Choi |
| title |
Microarray-Based Gene Expression Profiling to Elucidate Effectiveness of Fermented Codonopsis lanceolata in Mice |
| title_short |
Microarray-Based Gene Expression Profiling to Elucidate Effectiveness of Fermented Codonopsis lanceolata in Mice |
| title_full |
Microarray-Based Gene Expression Profiling to Elucidate Effectiveness of Fermented Codonopsis lanceolata in Mice |
| title_fullStr |
Microarray-Based Gene Expression Profiling to Elucidate Effectiveness of Fermented Codonopsis lanceolata in Mice |
| title_full_unstemmed |
Microarray-Based Gene Expression Profiling to Elucidate Effectiveness of Fermented Codonopsis lanceolata in Mice |
| title_sort |
microarray-based gene expression profiling to elucidate effectiveness of fermented codonopsis lanceolata in mice |
| publisher |
MDPI AG |
| series |
International Journal of Molecular Sciences |
| issn |
1422-0067 |
| publishDate |
2014-04-01 |
| description |
In this study, the effect of Codonopsis lanceolata fermented by lactic acid on controlling gene expression levels related to obesity was observed in an oligonucleotide chip microarray. Among 8170 genes, 393 genes were up regulated and 760 genes were down regulated in feeding the fermented C. lanceolata (FCL). Another 374 genes were up regulated and 527 genes down regulated without feeding the sample. The genes were not affected by the FCL sample. It was interesting that among those genes, Chytochrome P450, Dmbt1, LOC76487, and thyroid hormones, etc., were mostly up or down regulated. These genes are more related to lipid synthesis. We could conclude that the FCL possibly controlled the gene expression levels related to lipid synthesis, which resulted in reducing obesity. However, more detailed protein expression experiments should be carried out. |
| topic |
fermented Codonopsis lanceolata microarray gene expression obesity |
| url |
http://www.mdpi.com/1422-0067/15/4/5907 |
| work_keys_str_mv |
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