Neonatal thyroxine activation modifies epigenetic programming of the liver

Neonatal thyroxine activation modifies epigenetic programming of the liver

Whether thyroid hormones affect gene expression via DNA methylation is not well known. Here the authors show that type 2 deiodinase (D2) converts T4 to produce T3, which prevents DNA methylation of discrete areas in the neonatal liver. In the absence of D2, DNA methylation occurs and is associated w...

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Main Authors: Tatiana L. Fonseca, Tzintzuni Garcia, Gustavo W. Fernandes, T. Murlidharan Nair, Antonio C. Bianco
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24748-8
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spelling doaj-5587b3ecf19b472a84494cfe82d8da0a2021-07-25T11:38:54ZengNature Publishing GroupNature Communications2041-17232021-07-0112111110.1038/s41467-021-24748-8Neonatal thyroxine activation modifies epigenetic programming of the liverTatiana L. Fonseca0Tzintzuni Garcia1Gustavo W. Fernandes2T. Murlidharan Nair3Antonio C. Bianco4Section of Adult and Pediatric Endocrinology, Diabetes & Metabolism, University of ChicagoCenter for Translational Data Science, University of ChicagoSection of Adult and Pediatric Endocrinology, Diabetes & Metabolism, University of ChicagoDepartment of Biological Sciences and CS/Informatics, Indiana University South BendSection of Adult and Pediatric Endocrinology, Diabetes & Metabolism, University of ChicagoWhether thyroid hormones affect gene expression via DNA methylation is not well known. Here the authors show that type 2 deiodinase (D2) converts T4 to produce T3, which prevents DNA methylation of discrete areas in the neonatal liver. In the absence of D2, DNA methylation occurs and is associated with reduced chromatin accessibility in promoters and enhancers and affects gene expression.https://doi.org/10.1038/s41467-021-24748-8
collection DOAJ
language English
format Article
sources DOAJ
author Tatiana L. Fonseca
Tzintzuni Garcia
Gustavo W. Fernandes
T. Murlidharan Nair
Antonio C. Bianco
spellingShingle Tatiana L. Fonseca
Tzintzuni Garcia
Gustavo W. Fernandes
T. Murlidharan Nair
Antonio C. Bianco
Neonatal thyroxine activation modifies epigenetic programming of the liver
Nature Communications
author_facet Tatiana L. Fonseca
Tzintzuni Garcia
Gustavo W. Fernandes
T. Murlidharan Nair
Antonio C. Bianco
author_sort Tatiana L. Fonseca
title Neonatal thyroxine activation modifies epigenetic programming of the liver
title_short Neonatal thyroxine activation modifies epigenetic programming of the liver
title_full Neonatal thyroxine activation modifies epigenetic programming of the liver
title_fullStr Neonatal thyroxine activation modifies epigenetic programming of the liver
title_full_unstemmed Neonatal thyroxine activation modifies epigenetic programming of the liver
title_sort neonatal thyroxine activation modifies epigenetic programming of the liver
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-07-01
description Whether thyroid hormones affect gene expression via DNA methylation is not well known. Here the authors show that type 2 deiodinase (D2) converts T4 to produce T3, which prevents DNA methylation of discrete areas in the neonatal liver. In the absence of D2, DNA methylation occurs and is associated with reduced chromatin accessibility in promoters and enhancers and affects gene expression.
url https://doi.org/10.1038/s41467-021-24748-8
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AT tzintzunigarcia neonatalthyroxineactivationmodifiesepigeneticprogrammingoftheliver
AT gustavowfernandes neonatalthyroxineactivationmodifiesepigeneticprogrammingoftheliver
AT tmurlidharannair neonatalthyroxineactivationmodifiesepigeneticprogrammingoftheliver
AT antoniocbianco neonatalthyroxineactivationmodifiesepigeneticprogrammingoftheliver
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